Basic Information
ID: ALA3705201
Type: Binding
Description: Inhibition Assay: After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4), bovine serum albumin (0.5%), calcium chloride (4 mM), sodium chloride (150 mM) and human HDL (2 mg/ml), the EL enzyme was added (total volume was 20 μl). After 4-hour reaction at 37 C., non-esterified fatty acid (NEFA) generated from HDL by EL was measured with a commercially available assay kit and the amount of NEFA was used as an index of enzyme activity. Considering the enzyme activity without the inhibitor as a control value, the inhibition rate of each concentration of the present compound was calculated, and 50% inhibitory concentration (IC50 value) was calculated from an inhibition curve.
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3705201
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 365.41 | 3.95 | 3.95 |
| 400.49 | 2.99 | 2.99 |
| 346.42 | 4.39 | 4.39 |
| 394.46 | 2.59 | 2.59 |
| 373.37 | 2.65 | 2.65 |
| 420.49 | 3.34 | 3.34 |
| 426.50 | 5.12 | 5.12 |
| 401.47 | 2.23 | 2.23 |
| 392.24 | 2.21 | 2.21 |
| 389.44 | 3.12 | 3.12 |
| 419.47 | 2.39 | 2.39 |
| 383.41 | 3.06 | 3.06 |
| 384.40 | 2.45 | 2.45 |
| 333.35 | 1.90 | 1.90 |
| 419.47 | 2.39 | 2.39 |
| 438.48 | 3.26 | 3.26 |
| 415.48 | 3.65 | 3.65 |
| 420.49 | 3.12 | 3.12 |
| 425.42 | 3.67 | 3.67 |
| 406.47 | 2.68 | 2.68 |
| 406.47 | 2.99 | 2.99 |
| 403.47 | 3.51 | 3.51 |
| 447.50 | 3.71 | 3.71 |
| 421.48 | 2.79 | 2.79 |
| 455.95 | 4.37 | 4.37 |
| 471.57 | 4.87 | 4.87 |
| 435.44 | 2.58 | 2.58 |
| 417.45 | 2.44 | 2.44 |
| 450.91 | 3.70 | 3.70 |
| 439.50 | 3.85 | 3.85 |
| 453.52 | 4.16 | 4.16 |
| 416.47 | 3.05 | 3.05 |
| 467.91 | 4.44 | 4.44 |
| 436.52 | 3.42 | 3.42 |
| 449.92 | 4.31 | 4.31 |
| 420.46 | 1.78 | 1.78 |
| 453.92 | 3.04 | 3.04 |
| 449.50 | 2.39 | 2.39 |
| 473.94 | 4.51 | 4.51 |