Basic Information
ID: ALA3705266
Type: Binding
Description: Spectrophotometic Assay: Spectrophotometic Assay: This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a continuous method, that was derived by adapting a previous discontinuous assay (Bateman, R.C.J. 1989 J Neurosci Methods 30, 23-28).
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3705266
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 336.40 | 3.62 | 3.62 |
| 336.40 | 3.62 | 3.62 |
| 336.39 | 3.62 | 3.62 |
| 336.40 | 3.39 | 3.39 |
| 354.41 | 4.27 | 4.27 |
| 337.38 | 4.05 | 4.05 |
| 439.52 | 4.59 | 4.59 |
| 385.42 | 4.33 | 4.33 |
| 383.45 | 5.10 | 5.10 |
| 345.38 | 4.15 | 4.15 |
| 421.50 | 2.93 | 2.93 |
| 407.47 | 2.32 | 2.32 |
| 326.33 | 2.98 | 2.98 |
| 471.56 | 6.58 | 6.58 |
| 322.37 | 3.23 | 3.23 |
| 312.76 | 3.49 | 3.49 |
| 364.30 | 3.99 | 3.99 |
| 413.48 | 5.79 | 5.79 |
| 419.48 | 5.80 | 5.80 |
| 350.42 | 3.41 | 3.41 |
| 284.36 | 3.04 | 3.04 |
| 394.33 | 4.07 | 4.07 |
| 345.38 | 4.15 | 4.15 |
| 296.31 | 2.97 | 2.97 |
| 308.34 | 2.84 | 2.84 |
| 438.54 | 3.93 | 3.93 |
| 344.32 | 2.89 | 2.89 |
| 454.57 | 5.97 | 5.97 |
| 426.30 | 5.15 | 5.15 |
| 360.46 | 4.65 | 4.65 |
| 403.49 | 5.68 | 5.68 |
| 296.31 | 2.97 | 2.97 |
| 364.30 | 3.99 | 3.99 |
| 335.41 | 4.22 | 4.22 |
| 361.45 | 3.82 | 3.82 |
| 364.45 | 4.40 | 4.40 |
| 294.31 | 2.54 | 2.54 |
| 426.30 | 5.15 | 5.15 |
| 336.40 | 3.62 | 3.62 |
| 347.21 | 4.14 | 4.14 |
| 454.36 | 5.93 | 5.93 |
| 375.40 | 4.16 | 4.16 |
| 354.38 | 3.76 | 3.76 |
| 361.45 | 3.60 | 3.60 |
| 440.55 | 5.58 | 5.58 |
| 361.83 | 4.66 | 4.66 |
| 347.21 | 4.14 | 4.14 |
| 355.40 | 5.00 | 5.00 |
| 445.57 | 4.19 | 4.19 |
| 362.43 | 3.73 | 3.73 |
| 301.40 | 3.40 | 3.40 |
| 352.35 | 2.34 | 2.34 |
| 374.44 | 4.06 | 4.06 |
| 372.40 | 4.64 | 4.64 |
| 376.46 | 4.07 | 4.07 |
| 344.32 | 3.12 | 3.12 |
| 407.47 | 2.54 | 2.54 |
| 308.34 | 2.84 | 2.84 |
| 293.37 | 3.91 | 3.91 |
| 352.39 | 2.86 | 2.86 |
| 379.82 | 4.80 | 4.80 |
| 413.48 | 5.79 | 5.79 |
| 361.45 | 3.60 | 3.60 |
| 446.55 | 4.62 | 4.62 |
| 347.42 | 3.21 | 3.21 |
| 387.44 | 4.03 | 4.03 |
| 278.31 | 2.83 | 2.83 |
| 371.40 | 3.74 | 3.74 |
| 363.37 | 4.29 | 4.29 |
| 314.30 | 3.11 | 3.11 |
| 327.39 | 4.01 | 4.01 |
| 387.44 | 3.80 | 3.80 |
| 308.34 | 2.84 | 2.84 |
| 360.46 | 4.44 | 4.44 |
| 323.36 | 2.43 | 2.43 |
| 351.41 | 3.92 | 3.92 |
| 345.31 | 3.55 | 3.55 |
| 307.35 | 3.44 | 3.44 |
| 372.40 | 4.41 | 4.41 |
| 307.35 | 3.69 | 3.69 |
| 391.47 | 4.93 | 4.93 |
| 307.35 | 4.04 | 4.04 |
| 385.47 | 4.80 | 4.80 |
| 354.38 | 3.76 | 3.76 |
| 354.41 | 4.50 | 4.50 |
| 358.30 | 3.16 | 3.16 |
| 377.44 | 4.97 | 4.97 |
| 311.44 | 4.14 | 4.14 |
| 407.47 | 2.54 | 2.54 |
| 348.41 | 3.86 | 3.86 |
| 377.44 | 4.28 | 4.28 |
| 278.31 | 2.61 | 2.61 |
| 359.82 | 4.97 | 4.97 |
| 307.35 | 3.52 | 3.52 |
| 387.44 | 3.80 | 3.80 |
| 336.35 | 2.61 | 2.61 |
| 385.42 | 4.92 | 4.92 |
| 471.56 | 6.58 | 6.58 |
| 357.41 | 4.02 | 4.02 |
| 421.45 | 5.16 | 5.16 |
| 293.33 | 3.65 | 3.65 |
| 361.45 | 3.38 | 3.38 |
| 364.30 | 3.99 | 3.99 |
| 299.37 | 3.86 | 3.86 |
| 335.36 | 3.20 | 3.20 |
| 360.46 | 4.88 | 4.88 |
| 388.86 | 5.15 | 5.15 |
| 326.33 | 2.98 | 2.98 |
| 354.41 | 4.50 | 4.50 |
| 351.41 | 3.92 | 3.92 |
| 336.40 | 3.39 | 3.39 |
| 347.21 | 4.14 | 4.14 |
| 364.30 | 3.99 | 3.99 |
| 364.45 | 3.76 | 3.76 |
| 363.42 | 2.67 | 2.67 |
| 438.54 | 4.16 | 4.16 |
| 397.87 | 3.32 | 3.32 |
| 314.30 | 2.88 | 2.88 |
| 296.31 | 2.97 | 2.97 |
| 476.58 | 6.69 | 6.69 |
| 423.30 | 5.81 | 5.81 |
| 350.42 | 4.01 | 4.01 |
| 426.52 | 5.54 | 5.54 |
| 312.76 | 3.49 | 3.49 |
| 388.86 | 5.15 | 5.15 |
| 375.43 | 4.49 | 4.49 |
| 312.76 | 3.49 | 3.49 |
| 354.41 | 4.50 | 4.50 |
| 363.42 | 4.15 | 4.15 |
| 376.46 | 4.55 | 4.55 |
| 352.35 | 2.57 | 2.57 |
| 396.28 | 5.32 | 5.32 |
| 408.46 | 2.97 | 2.97 |
| 365.29 | 4.42 | 4.42 |
| 347.21 | 4.14 | 4.14 |
| 366.42 | 3.20 | 3.20 |
| 285.35 | 3.47 | 3.47 |
| 362.43 | 4.02 | 4.02 |
| 323.31 | 2.99 | 2.99 |
| 322.37 | 3.23 | 3.23 |
| 297.29 | 3.40 | 3.40 |
| 364.41 | 3.10 | 3.10 |
| 377.45 | 3.01 | 3.01 |
| 315.28 | 3.54 | 3.54 |
| 374.44 | 4.39 | 4.39 |
| 337.34 | 2.80 | 2.80 |
| 351.41 | 4.36 | 4.36 |
| 396.44 | 5.13 | 5.13 |
| 361.45 | 5.08 | 5.08 |
| 337.34 | 3.03 | 3.03 |
| 365.44 | 2.77 | 2.77 |
| 349.44 | 3.68 | 3.68 |
| 389.84 | 5.58 | 5.58 |
| 355.40 | 4.93 | 4.93 |
| 383.45 | 5.10 | 5.10 |
| 364.41 | 3.10 | 3.10 |
| 407.47 | 2.54 | 2.54 |
| 313.74 | 3.91 | 3.91 |
| 377.45 | 3.01 | 3.01 |
| 362.43 | 3.80 | 3.80 |
| 410.47 | 3.36 | 3.36 |
| 364.41 | 2.87 | 2.87 |
| 389.84 | 5.58 | 5.58 |
| 439.52 | 4.36 | 4.36 |
| 279.30 | 3.26 | 3.26 |
| 385.42 | 4.33 | 4.33 |
| 362.43 | 4.25 | 4.25 |
| 375.48 | 3.64 | 3.64 |
| 351.41 | 3.84 | 3.84 |
| 245.28 | 2.54 | 2.54 |
| 362.43 | 4.25 | 4.25 |
| 359.82 | 4.97 | 4.97 |
| 293.33 | 3.57 | 3.57 |
| 313.74 | 3.91 | 3.91 |
| 350.42 | 4.11 | 4.11 |
| 293.33 | 3.57 | 3.57 |
| 361.45 | 4.86 | 4.86 |
| 297.29 | 3.40 | 3.40 |
| 439.52 | 4.59 | 4.59 |
| 353.38 | 3.29 | 3.29 |