Basic Information
ID: ALA3705409
Type: Binding
Description: Enzyme Inhibition Assay: The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the human FGFR2 enzyme prepared using a baculovirus expression system. Phosphorylated biotinylated peptides were detected by the time-resolved fluorescent measurement using a europium cryptate-linked anti-phophotyrosine antibody and a streptavidin to which XL665, a derivative of allophycocyanine, is linked. The 50% inhibitory concentration (IC50) was calculated based on the inhibitory rate against the control group without test substances.
Format: BAO_0000019
Organism: Homo sapiens
Target: Fibroblast growth factor receptor 2(ALA4142)
Document: ALA3639106
BindingDB Source: 6472
Activity Charts
Bioactivity
Activity Types for Assay ALA3705409
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 358.41 | 2.42 | 2.42 |
| 469.55 | 3.31 | 3.31 |
| 454.54 | 2.76 | 2.76 |
| 485.55 | 3.06 | 3.06 |
| 456.51 | 3.91 | 3.91 |
| 453.27 | 4.25 | 4.25 |
| 450.48 | 5.16 | 5.16 |
| 500.48 | 6.04 | 6.04 |
| 503.51 | 4.22 | 4.22 |
| 481.44 | 3.64 | 3.64 |
| 501.47 | 5.43 | 5.43 |
| 386.42 | 2.84 | 2.84 |
| 498.59 | 2.98 | 2.98 |
| 456.51 | 3.77 | 3.77 |
| 503.61 | 3.04 | 3.04 |
| 437.51 | 3.42 | 3.42 |
| 469.55 | 3.57 | 3.57 |
| 435.29 | 4.11 | 4.11 |
| 357.38 | 2.75 | 2.75 |
| 482.29 | 3.96 | 3.96 |
| 370.42 | 3.66 | 3.66 |
| 398.47 | 4.47 | 4.47 |
| 446.51 | 4.94 | 4.94 |
| 502.50 | 6.02 | 6.02 |
| 380.41 | 3.33 | 3.33 |
| 374.38 | 3.49 | 3.49 |
| 428.50 | 4.53 | 4.53 |
| 449.50 | 2.72 | 2.72 |
| 518.58 | 4.25 | 4.25 |
| 412.50 | 4.69 | 4.69 |
| 436.48 | 3.75 | 3.75 |
| 463.50 | 4.42 | 4.42 |
| 396.45 | 4.23 | 4.23 |
| 462.51 | 5.03 | 5.03 |
| 432.49 | 5.02 | 5.02 |
| 511.57 | 3.82 | 3.82 |
| 434.46 | 3.81 | 3.81 |
| 430.47 | 3.38 | 3.38 |
| 426.48 | 4.14 | 4.14 |
| 436.38 | 3.67 | 3.67 |
| 451.47 | 4.55 | 4.55 |
| 460.93 | 4.79 | 4.79 |
| 390.83 | 4.00 | 4.00 |
| 356.39 | 3.35 | 3.35 |
| 424.39 | 4.37 | 4.37 |
| 374.38 | 3.49 | 3.49 |
| 549.60 | 5.96 | 5.96 |
| 383.42 | 2.31 | 2.31 |
| 437.51 | 3.73 | 3.73 |
| 457.51 | 3.96 | 3.96 |
| 481.60 | 4.94 | 4.94 |
| 433.48 | 4.41 | 4.41 |
| 449.47 | 4.12 | 4.12 |
| 453.55 | 4.16 | 4.16 |
| 467.58 | 4.72 | 4.72 |
| 471.54 | 4.29 | 4.29 |
| 489.53 | 4.79 | 4.79 |
| 507.64 | 5.47 | 5.47 |
| 385.23 | 2.96 | 2.96 |
| 306.33 | 2.20 | 2.20 |
| 400.42 | 4.00 | 4.00 |
| 455.52 | 3.18 | 3.18 |
| 484.56 | 3.10 | 3.10 |
| 482.55 | 2.74 | 2.74 |
| 429.48 | 3.41 | 3.41 |
| 445.48 | 2.12 | 2.12 |
| 476.54 | 4.40 | 4.40 |
| 441.50 | 3.19 | 3.19 |
| 469.51 | 2.82 | 2.82 |
| 410.36 | 4.06 | 4.06 |
| 370.42 | 3.61 | 3.61 |
| 432.49 | 4.63 | 4.63 |
| 534.65 | 2.23 | 2.23 |
| 454.54 | 2.76 | 2.76 |
| 496.58 | 3.02 | 3.02 |
| 468.57 | 3.10 | 3.10 |
| 439.52 | 3.95 | 3.95 |
| 374.38 | 3.49 | 3.49 |
| 475.53 | 1.06 | 1.06 |
| 400.40 | 3.05 | 3.05 |
| 416.44 | 3.37 | 3.37 |
| 386.42 | 3.36 | 3.36 |
| 384.44 | 3.97 | 3.97 |
| 412.50 | 4.65 | 4.65 |
| 448.49 | 5.14 | 5.14 |
| 402.48 | 4.07 | 4.07 |
| 442.38 | 4.51 | 4.51 |
| 420.86 | 4.01 | 4.01 |
| 462.51 | 4.93 | 4.93 |
| 414.47 | 4.14 | 4.14 |
| 414.43 | 3.12 | 3.12 |
| 468.61 | 5.95 | 5.95 |
| 422.45 | 3.54 | 3.54 |
| 456.45 | 4.96 | 4.96 |
| 489.53 | 4.58 | 4.58 |
| 428.45 | 3.13 | 3.13 |
| 372.39 | 3.06 | 3.06 |
| 434.48 | 2.76 | 2.76 |
| 464.12 | 3.72 | 3.72 |
| 460.50 | 4.32 | 4.32 |