Basic Information
ID: ALA3705549
Type: Binding
Description: Inhibition Assay: The activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximity assay (SPA) modified from the Amersham TRKQ7100 instructions (GE Healthcare, USA).
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3705549
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 393.43 | 2.86 | 2.86 |
| 389.46 | 3.03 | 3.03 |
| 411.42 | 3.00 | 3.00 |
| 431.40 | 3.68 | 3.68 |
| 461.42 | 3.69 | 3.69 |
| 414.40 | 3.12 | 3.12 |
| 359.44 | 3.02 | 3.02 |
| 379.86 | 3.36 | 3.36 |
| 380.84 | 2.76 | 2.76 |
| 369.38 | 3.48 | 3.48 |
| 388.36 | 2.96 | 2.96 |
| 403.37 | 2.74 | 2.74 |
| 398.83 | 2.90 | 2.90 |
| 399.38 | 3.42 | 3.42 |
| 413.41 | 3.73 | 3.73 |
| 449.39 | 3.97 | 3.97 |
| 373.46 | 3.27 | 3.27 |
| 345.41 | 2.71 | 2.71 |
| 375.44 | 2.72 | 2.72 |
| 360.43 | 2.41 | 2.41 |
| 376.42 | 2.11 | 2.11 |
| 393.43 | 2.86 | 2.86 |
| 429.41 | 3.10 | 3.10 |
| 412.40 | 2.36 | 2.36 |
| 396.41 | 2.66 | 2.66 |
| 415.84 | 3.61 | 3.61 |
| 411.42 | 2.96 | 2.96 |
| 395.42 | 3.26 | 3.26 |
| 409.88 | 2.99 | 2.99 |
| 405.46 | 2.34 | 2.34 |
| 389.46 | 2.64 | 2.64 |
| 390.45 | 2.04 | 2.04 |
| 454.33 | 3.10 | 3.10 |
| 443.43 | 3.35 | 3.35 |
| 333.40 | 2.85 | 2.85 |
| 397.85 | 3.50 | 3.50 |
| 371.81 | 3.33 | 3.33 |
| 367.39 | 2.69 | 2.69 |
| 353.82 | 3.20 | 3.20 |
| 378.42 | 2.55 | 2.55 |
| 349.40 | 2.55 | 2.55 |
| 352.38 | 2.38 | 2.38 |
| 448.84 | 3.78 | 3.78 |
| 432.39 | 3.26 | 3.26 |
| 363.43 | 2.86 | 2.86 |
| 367.39 | 2.69 | 2.69 |
| 385.38 | 2.83 | 2.83 |
| 403.37 | 3.44 | 3.44 |
| 337.36 | 2.68 | 2.68 |
| 395.42 | 3.65 | 3.65 |
| 393.88 | 3.67 | 3.67 |
| 438.42 | 3.60 | 3.60 |
| 427.87 | 3.32 | 3.32 |
| 381.39 | 2.99 | 2.99 |
| 409.88 | 3.37 | 3.37 |
| 443.43 | 3.74 | 3.74 |
| 404.87 | 3.24 | 3.24 |
| 412.38 | 3.43 | 3.43 |
| 363.40 | 2.85 | 2.85 |
| 384.45 | 2.89 | 2.89 |
| 396.41 | 3.04 | 3.04 |
| 388.44 | 2.31 | 2.31 |
| 354.81 | 2.59 | 2.59 |
| 378.83 | 3.07 | 3.07 |
| 424.31 | 3.47 | 3.47 |
| 411.42 | 3.31 | 3.31 |
| 415.38 | 2.52 | 2.52 |
| 391.40 | 2.01 | 2.01 |
| 505.53 | 4.75 | 4.75 |
| 518.42 | 4.91 | 4.91 |
| 398.27 | 3.30 | 3.30 |
| 385.38 | 3.14 | 3.14 |
| 410.43 | 3.22 | 3.22 |
| 358.41 | 2.72 | 2.72 |
| 425.29 | 2.87 | 2.87 |
| 389.35 | 2.35 | 2.35 |
| 401.40 | 3.59 | 3.59 |
| 445.42 | 3.99 | 3.99 |
| 449.39 | 3.82 | 3.82 |
| 487.45 | 2.46 | 2.46 |
| 486.46 | 3.06 | 3.06 |
| 432.49 | 2.35 | 2.35 |
| 452.91 | 2.70 | 2.70 |
| 387.37 | 3.56 | 3.56 |