Basic Information
ID: ALA3705556
Type: Binding
Description: Inhibition Assay: Inhibition of human t-PA was determined by the method described in [0092]-[0098] using recombinant human tissue-type plasminogen activator (Actilyse®) from Boehringer Ingelheim at 290 U/mL and Mes-d-Cha-Gly-Arg-pNA (Pefachrome tPA) at 4 mM, 2 mM, and 1 mM as substrate; results are reported as Ki values (nanomolar).
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3705556
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 444.56 | 1.45 | 1.45 |
| 690.87 | 3.06 | 3.06 |
| 681.90 | 2.38 | 2.38 |
| 653.89 | 2.51 | 2.51 |
| 707.94 | 2.77 | 2.77 |
| 695.93 | 2.77 | 2.77 |
| 695.93 | 2.77 | 2.77 |
| 639.87 | 2.12 | 2.12 |
| 711.93 | 2.00 | 2.00 |
| 633.82 | 2.37 | 2.37 |
| 710.95 | 2.51 | 2.51 |
| 696.92 | 2.17 | 2.17 |
| 697.90 | 2.60 | 2.60 |
| 663.85 | 2.00 | 2.00 |
| 709.96 | 3.01 | 3.01 |
| 646.86 | 3.36 | 3.36 |
| 649.82 | 1.61 | 1.61 |
| 711.93 | 2.99 | 2.99 |
| 647.85 | 2.76 | 2.76 |
| 638.80 | 0.81 | 0.81 |