Basic Information
ID: ALA3705564
Type: Binding
Description: Inhibition Assay: Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF is hydroxylated on a conserved prolyl radical. It is the basis for the biochemical determination of HIF prolyl hydroxylase activity. The test is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. Biochem. 330 (1), 74-80 (2004)].
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3705564
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 242.24 | 0.45 | 0.45 |
| 311.35 | 1.13 | 1.13 |
| 325.25 | 1.26 | 1.26 |
| 269.27 | 0.41 | 0.41 |
| 243.23 | -0.16 | -0.16 |
| 300.32 | 0.76 | 0.76 |
| 242.24 | 1.52 | 1.52 |
| 241.25 | 1.05 | 1.05 |
| 324.27 | 1.72 | 1.72 |
| 321.14 | 1.21 | 1.21 |
| 328.33 | 1.10 | 1.10 |
| 314.31 | -0.63 | -0.63 |
| 296.21 | 1.16 | 1.16 |
| 314.35 | 1.57 | 1.57 |
| 255.28 | 1.36 | 1.36 |
| 299.29 | -0.68 | -0.68 |
| 289.32 | 0.65 | 0.65 |
| 330.38 | 0.09 | 0.09 |
| 326.36 | 0.77 | 0.77 |
| 341.38 | 0.76 | 0.76 |