Basic Information
ID: ALA3705621
Type: Binding
Description: Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
Format: BAO_0000219
Organism: Rattus norvegicus
Cell type: HEK293
Target: Serotonin 7 (5-HT7) receptor(ALA3223)
Document: ALA3638852
BindingDB Source: 6682
Activity Charts
Bioactivity
Activity Types for Assay ALA3705621
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 323.31 | 3.73 | 3.73 |
| 287.33 | 3.16 | 3.16 |
| 280.33 | 2.58 | 2.58 |
| 283.37 | 3.33 | 3.33 |
| 287.33 | 3.16 | 3.16 |
| 283.37 | 3.33 | 3.33 |
| 339.31 | 3.61 | 3.61 |
| 269.34 | 3.02 | 3.02 |
| 285.34 | 2.72 | 2.72 |
| 357.76 | 4.39 | 4.39 |
| 269.34 | 3.02 | 3.02 |
| 287.33 | 3.16 | 3.16 |
| 269.34 | 3.02 | 3.02 |
| 283.37 | 3.33 | 3.33 |
| 255.32 | 2.71 | 2.71 |
| 283.37 | 3.33 | 3.33 |
| 289.76 | 3.37 | 3.37 |
| 331.84 | 4.49 | 4.49 |
| 343.85 | 4.63 | 4.63 |
| 293.29 | 3.72 | 3.72 |
| 259.74 | 3.36 | 3.36 |
| 239.32 | 3.01 | 3.01 |
| 239.32 | 3.01 | 3.01 |
| 294.18 | 4.01 | 4.01 |
| 327.73 | 4.38 | 4.38 |
| 273.76 | 3.67 | 3.67 |
| 273.76 | 3.67 | 3.67 |
| 318.30 | 3.59 | 3.59 |
| 250.30 | 2.58 | 2.58 |
| 264.33 | 2.88 | 2.88 |
| 264.33 | 2.88 | 2.88 |
| 283.37 | 3.41 | 3.41 |
| 337.34 | 3.95 | 3.95 |
| 309.41 | 3.94 | 3.94 |
| 309.41 | 3.80 | 3.80 |
| 297.40 | 3.80 | 3.80 |
| 392.42 | 4.21 | 4.21 |
| 273.76 | 3.67 | 3.67 |
| 291.75 | 3.81 | 3.81 |
| 287.79 | 3.97 | 3.97 |
| 267.37 | 3.75 | 3.75 |
| 285.36 | 3.89 | 3.89 |
| 289.32 | 3.72 | 3.72 |
| 321.34 | 4.46 | 4.46 |
| 321.34 | 4.46 | 4.46 |
| 337.34 | 4.34 | 4.34 |
| 253.34 | 3.44 | 3.44 |
| 267.37 | 3.78 | 3.78 |
| 223.32 | 3.43 | 3.43 |
| 237.35 | 3.74 | 3.74 |
| 251.37 | 4.08 | 4.08 |
| 237.35 | 3.74 | 3.74 |
| 251.37 | 4.08 | 4.08 |
| 257.76 | 4.08 | 4.08 |
| 251.37 | 4.05 | 4.05 |
| 265.40 | 4.39 | 4.39 |
| 237.35 | 3.74 | 3.74 |
| 251.37 | 4.08 | 4.08 |
| 253.34 | 3.44 | 3.44 |
| 267.37 | 3.78 | 3.78 |
| 267.37 | 3.75 | 3.75 |
| 292.21 | 4.74 | 4.74 |
| 289.78 | 4.53 | 4.53 |
| 285.82 | 4.70 | 4.70 |
| 283.37 | 3.49 | 3.49 |
| 351.37 | 4.51 | 4.51 |