Basic Information
ID: ALA3705630
Type: Binding
Description: Enzyme Assay-Time Dependence: Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay that couples the production of glutamate (liberated by GAC) to glutamate dehydrogenase (GDH) and measuring the change in absorbance for the reduction of NAD+ to NADH.
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3705630
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 524.70 | 4.27 | 4.27 |
| 552.68 | 3.38 | 3.38 |
| 524.63 | 3.30 | 3.30 |
| 682.49 | 5.80 | 5.80 |
| 907.20 | 6.33 | 6.33 |
| 682.42 | 4.82 | 4.82 |
| 486.60 | 4.26 | 4.26 |
| 593.52 | 4.61 | 4.61 |
| 532.63 | 3.76 | 3.76 |
| 537.05 | 4.40 | 4.40 |
| 750.95 | 6.37 | 6.37 |
| 550.71 | 3.23 | 3.23 |
| 615.76 | 5.28 | 5.28 |
| 515.64 | 3.71 | 3.71 |
| 543.07 | 4.46 | 4.46 |
| 502.60 | 3.75 | 3.75 |
| 515.64 | 3.71 | 3.71 |
| 621.79 | 5.34 | 5.34 |
| 587.71 | 4.50 | 4.50 |
| 587.71 | 4.50 | 4.50 |
| 678.22 | 4.67 | 4.67 |
| 635.82 | 5.68 | 5.68 |
| 572.72 | 4.56 | 4.56 |
| 535.70 | 4.04 | 4.04 |
| 549.73 | 4.38 | 4.38 |
| 566.69 | 4.50 | 4.50 |
| 629.79 | 5.62 | 5.62 |
| 546.65 | 4.27 | 4.27 |
| 546.65 | 4.27 | 4.27 |
| 601.73 | 5.60 | 5.60 |
| 601.73 | 5.60 | 5.60 |
| 615.76 | 5.28 | 5.28 |
| 586.72 | 4.95 | 4.95 |
| 479.61 | 4.14 | 4.14 |
| 673.80 | 4.03 | 4.03 |
| 501.62 | 4.40 | 4.40 |
| 543.70 | 4.32 | 4.32 |
| 515.64 | 3.71 | 3.71 |
| 529.67 | 3.98 | 3.98 |
| 501.62 | 3.84 | 3.84 |
| 501.62 | 3.84 | 3.84 |
| 418.91 | 2.80 | 2.80 |
| 497.63 | 3.68 | 3.68 |
| 570.60 | 5.15 | 5.15 |
| 572.59 | 5.41 | 5.41 |
| 581.50 | 4.51 | 4.51 |
| 537.67 | 4.47 | 4.47 |
| 521.67 | 4.77 | 4.77 |
| 439.55 | 3.22 | 3.22 |
| 487.59 | 4.72 | 4.72 |
| 568.70 | 4.24 | 4.24 |
| 468.59 | 2.67 | 2.67 |
| 666.20 | 5.42 | 5.42 |
| 566.09 | 3.86 | 3.86 |
| 539.66 | 4.06 | 4.06 |
| 439.55 | 2.49 | 2.49 |
| 543.65 | 4.21 | 4.21 |
| 546.65 | 3.63 | 3.63 |
| 560.68 | 4.28 | 4.28 |
| 629.79 | 5.32 | 5.32 |
| 586.72 | 3.76 | 3.76 |
| 557.68 | 3.89 | 3.89 |
| 619.75 | 5.19 | 5.19 |
| 599.76 | 4.92 | 4.92 |
| 600.75 | 3.43 | 3.43 |
| 633.78 | 5.11 | 5.11 |
| 629.79 | 5.84 | 5.84 |
| 521.67 | 3.78 | 3.78 |
| 459.60 | 3.67 | 3.67 |
| 607.14 | 5.75 | 5.75 |
| 628.76 | 3.53 | 3.53 |
| 529.67 | 3.76 | 3.76 |
| 642.79 | 3.20 | 3.20 |
| 522.58 | 4.53 | 4.53 |
| 647.81 | 5.46 | 5.46 |
| 571.71 | 4.23 | 4.23 |
| 587.49 | 4.54 | 4.54 |
| 621.04 | 5.30 | 5.30 |
| 571.49 | 5.05 | 5.05 |
| 724.07 | 7.50 | 7.50 |
| 578.70 | 6.05 | 6.05 |
| 543.65 | 4.21 | 4.21 |
| 593.74 | 3.31 | 3.31 |
| 586.72 | 4.08 | 4.08 |
| 571.71 | 3.93 | 3.93 |
| 633.78 | 5.23 | 5.23 |
| 572.69 | 4.36 | 4.36 |
| 586.72 | 3.76 | 3.76 |
| 611.65 | 4.43 | 4.43 |
| 481.58 | 2.67 | 2.67 |
| 543.65 | 3.96 | 3.96 |
| 523.66 | 3.70 | 3.70 |
| 557.68 | 3.89 | 3.89 |
| 501.62 | 3.59 | 3.59 |
| 615.76 | 5.28 | 5.28 |
| 544.64 | 3.88 | 3.88 |
| 515.64 | 3.71 | 3.71 |
| 567.07 | 4.41 | 4.41 |
| 551.07 | 4.96 | 4.96 |
| 516.63 | 4.26 | 4.26 |
| 599.76 | 4.57 | 4.57 |
| 613.79 | 4.96 | 4.96 |
| 571.71 | 3.89 | 3.89 |
| 597.75 | 4.42 | 4.42 |
| 647.75 | 5.06 | 5.06 |
| 700.62 | 4.74 | 4.74 |
| 597.75 | 4.77 | 4.77 |
| 582.73 | 3.60 | 3.60 |
| 583.72 | 4.38 | 4.38 |
| 593.71 | 5.23 | 5.23 |
| 625.80 | 5.06 | 5.06 |
| 574.71 | 4.41 | 4.41 |
| 613.79 | 5.06 | 5.06 |
| 599.76 | 4.67 | 4.67 |
| 613.79 | 4.91 | 4.91 |
| 585.73 | 4.28 | 4.28 |
| 583.72 | 4.03 | 4.03 |
| 530.65 | 4.65 | 4.65 |
| 629.79 | 5.84 | 5.84 |
| 612.76 | 3.64 | 3.64 |
| 539.66 | 4.06 | 4.06 |
| 633.75 | 5.42 | 5.42 |
| 702.86 | 5.45 | 5.45 |
| 602.74 | 3.80 | 3.80 |
| 599.76 | 4.71 | 4.71 |
| 599.76 | 4.71 | 4.71 |
| 585.73 | 4.32 | 4.32 |
| 599.76 | 4.67 | 4.67 |
| 492.63 | 4.32 | 4.32 |
| 566.69 | 4.50 | 4.50 |
| 572.69 | 4.36 | 4.36 |
| 546.65 | 3.63 | 3.63 |
| 492.63 | 4.32 | 4.32 |
| 638.75 | 4.78 | 4.78 |
| 576.68 | 2.99 | 2.99 |
| 664.79 | 5.75 | 5.75 |
| 661.79 | 3.92 | 3.92 |
| 645.79 | 5.43 | 5.43 |
| 645.79 | 5.43 | 5.43 |
| 581.74 | 5.08 | 5.08 |
| 548.70 | 4.05 | 4.05 |
| 526.63 | 4.13 | 4.13 |
| 562.74 | 4.88 | 4.88 |
| 615.76 | 3.69 | 3.69 |
| 534.62 | 4.40 | 4.40 |
| 603.79 | 5.03 | 5.03 |
| 603.79 | 4.88 | 4.88 |
| 584.75 | 5.12 | 5.12 |
| 564.71 | 4.33 | 4.33 |
| 504.59 | 4.40 | 4.40 |
| 521.05 | 4.91 | 4.91 |
| 521.05 | 4.91 | 4.91 |
| 500.63 | 4.56 | 4.56 |
| 644.78 | 4.06 | 4.06 |
| 653.81 | 4.83 | 4.83 |
| 613.74 | 3.03 | 3.03 |
| 551.07 | 4.92 | 4.92 |
| 534.62 | 4.40 | 4.40 |
| 539.04 | 5.05 | 5.05 |
| 522.58 | 4.53 | 4.53 |
| 535.07 | 5.22 | 5.22 |
| 518.62 | 4.70 | 4.70 |
| 534.62 | 4.40 | 4.40 |
| 520.59 | 4.10 | 4.10 |
| 560.68 | 4.02 | 4.02 |
| 564.64 | 3.77 | 3.77 |
| 629.79 | 5.84 | 5.84 |
| 599.76 | 4.71 | 4.71 |
| 629.79 | 5.84 | 5.84 |
| 534.62 | 4.40 | 4.40 |
| 539.04 | 5.05 | 5.05 |
| 554.60 | 5.27 | 5.27 |
| 560.68 | 4.66 | 4.66 |
| 555.49 | 5.56 | 5.56 |
| 539.04 | 5.05 | 5.05 |
| 530.65 | 4.57 | 4.57 |
| 599.76 | 4.73 | 4.73 |
| 715.88 | 5.98 | 5.98 |
| 587.71 | 4.67 | 4.67 |
| 532.63 | 3.97 | 3.97 |
| 601.73 | 5.06 | 5.06 |
| 546.65 | 4.36 | 4.36 |
| 556.74 | 6.02 | 6.02 |
| 560.68 | 4.54 | 4.54 |
| 529.67 | 4.28 | 4.28 |
| 529.67 | 4.28 | 4.28 |
| 601.73 | 5.06 | 5.06 |
| 601.73 | 5.06 | 5.06 |
| 599.76 | 4.92 | 4.92 |
| 555.49 | 5.56 | 5.56 |
| 539.04 | 5.05 | 5.05 |
| 745.90 | 5.51 | 5.51 |
| 647.78 | 5.98 | 5.98 |
| 647.78 | 5.76 | 5.76 |
| 747.87 | 5.75 | 5.75 |
| 744.92 | 6.31 | 6.31 |
| 688.81 | 4.75 | 4.75 |
| 660.76 | 3.97 | 3.97 |
| 619.72 | 5.20 | 5.20 |
| 601.73 | 3.64 | 3.64 |
| 663.80 | 5.38 | 5.38 |
| 655.70 | 4.19 | 4.19 |
| 669.73 | 4.58 | 4.58 |
| 671.82 | 4.66 | 4.66 |
| 631.76 | 2.86 | 2.86 |
| 532.63 | 3.97 | 3.97 |
| 622.77 | 4.07 | 4.07 |
| 452.46 | 3.56 | 3.56 |
| 570.60 | 5.15 | 5.15 |
| 699.76 | 6.18 | 6.18 |
| 604.74 | 6.05 | 6.05 |
| 602.72 | 4.83 | 4.83 |
| 587.71 | 4.67 | 4.67 |
| 571.71 | 4.45 | 4.45 |
| 619.72 | 5.01 | 5.01 |
| 601.73 | 5.06 | 5.06 |
| 530.65 | 4.31 | 4.31 |
| 615.76 | 5.62 | 5.62 |
| 544.68 | 4.87 | 4.87 |
| 685.73 | 5.96 | 5.96 |
| 614.65 | 5.21 | 5.21 |
| 615.76 | 5.45 | 5.45 |
| 661.80 | 6.32 | 6.32 |
| 671.70 | 5.40 | 5.40 |
| 601.73 | 5.23 | 5.23 |
| 615.76 | 5.62 | 5.62 |
| 643.81 | 6.40 | 6.40 |
| 685.73 | 4.33 | 4.33 |
| 699.76 | 4.72 | 4.72 |
| 669.73 | 4.75 | 4.75 |
| 683.76 | 5.14 | 5.14 |
| 627.77 | 5.51 | 5.51 |
| 617.73 | 4.65 | 4.65 |
| 601.73 | 5.06 | 5.06 |
| 530.65 | 4.31 | 4.31 |
| 711.77 | 6.41 | 6.41 |
| 514.66 | 5.38 | 5.38 |
| 570.60 | 5.15 | 5.15 |
| 570.60 | 5.15 | 5.15 |
| 500.63 | 4.82 | 4.82 |
| 600.62 | 5.16 | 5.16 |
| 605.04 | 5.81 | 5.81 |
| 547.73 | 5.15 | 5.15 |
| 599.76 | 5.09 | 5.09 |
| 589.77 | 5.16 | 5.16 |
| 625.68 | 5.00 | 5.00 |
| 626.81 | 4.38 | 4.38 |
| 643.74 | 5.70 | 5.70 |
| 617.82 | 5.79 | 5.79 |
| 611.79 | 4.18 | 4.18 |
| 560.64 | 3.72 | 3.72 |
| 574.66 | 3.81 | 3.81 |
| 670.71 | 5.85 | 5.85 |
| 643.81 | 6.02 | 6.02 |
| 643.81 | 6.02 | 6.02 |
| 547.73 | 4.76 | 4.76 |
| 543.70 | 4.45 | 4.45 |
| 578.72 | 3.80 | 3.80 |
| 578.72 | 3.80 | 3.80 |
| 584.62 | 5.72 | 5.72 |
| 624.83 | 5.28 | 5.28 |
| 615.76 | 4.50 | 4.50 |
| 615.76 | 4.41 | 4.41 |
| 582.69 | 4.54 | 4.54 |
| 611.65 | 4.76 | 4.76 |
| 527.65 | 3.86 | 3.86 |
| 569.69 | 4.12 | 4.12 |
| 582.69 | 4.54 | 4.54 |
| 647.78 | 5.98 | 5.98 |
| 647.78 | 5.98 | 5.98 |
| 547.66 | 4.41 | 4.41 |
| 547.66 | 4.41 | 4.41 |
| 452.46 | 3.56 | 3.56 |
| 600.62 | 5.16 | 5.16 |
| 606.58 | 5.43 | 5.43 |
| 654.59 | 6.05 | 6.05 |
| 588.59 | 5.29 | 5.29 |
| 606.58 | 5.43 | 5.43 |
| 606.58 | 5.43 | 5.43 |
| 552.61 | 4.86 | 4.86 |
| 584.62 | 5.20 | 5.20 |
| 552.61 | 4.86 | 4.86 |
| 584.62 | 5.20 | 5.20 |
| 636.60 | 5.76 | 5.76 |
| 668.62 | 6.10 | 6.10 |
| 571.59 | 4.55 | 4.55 |
| 571.59 | 4.55 | 4.55 |
| 571.59 | 4.55 | 4.55 |
| 588.59 | 5.29 | 5.29 |
| 616.69 | 5.88 | 5.88 |
| 754.96 | 6.32 | 6.32 |
| 554.73 | 3.19 | 3.19 |
| 580.65 | 3.66 | 3.66 |
| 524.63 | 3.30 | 3.30 |
| 556.70 | 3.25 | 3.25 |
| 606.82 | 4.18 | 4.18 |
| 552.68 | 4.08 | 4.08 |
| 638.80 | 3.54 | 3.54 |
| 726.91 | 2.00 | 2.00 |
| 612.80 | 4.38 | 4.38 |
| 580.74 | 4.43 | 4.43 |
| 552.68 | 4.61 | 4.61 |
| 508.56 | 2.05 | 2.05 |
| 488.50 | -0.50 | -0.50 |
| 580.74 | 3.82 | 3.82 |
| 522.66 | 3.23 | 3.23 |
| 660.87 | 6.94 | 6.94 |
| 664.81 | 5.62 | 5.62 |
| 612.73 | 2.80 | 2.80 |
| 612.73 | 2.80 | 2.80 |
| 694.82 | 4.17 | 4.17 |
| 446.56 | 2.46 | 2.46 |
| 537.05 | 4.40 | 4.40 |
| 502.60 | 3.75 | 3.75 |
| 538.58 | 4.03 | 4.03 |
| 446.56 | 3.70 | 3.70 |
| 621.79 | 4.03 | 4.03 |
| 655.70 | 4.19 | 4.19 |
| 560.68 | 4.02 | 4.02 |
| 460.49 | 3.38 | 3.38 |
| 526.67 | 3.06 | 3.06 |
| 594.73 | 5.41 | 5.41 |
| 572.68 | 4.07 | 4.07 |
| 594.73 | 5.41 | 5.41 |
| 620.80 | 4.97 | 4.97 |
| 584.75 | 4.03 | 4.03 |