Basic Information
ID: ALA3705631
Type: Binding
Description: Enzyme Assay: Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay that couples the production of glutamate (liberated by GAC) to glutamate dehydrogenase (GDH) and measuring the change in absorbance for the reduction of NAD+ to NADH.
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3705631
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 524.70 | 4.27 | 4.27 |
| 406.56 | 2.67 | 2.67 |
| 496.64 | 4.41 | 4.41 |
| 556.70 | 4.43 | 4.43 |
| 456.66 | 3.88 | 3.88 |
| 488.57 | 0.91 | 0.91 |
| 552.75 | 4.32 | 4.32 |
| 624.81 | 4.97 | 4.97 |
| 724.93 | 5.66 | 5.66 |
| 520.68 | 4.95 | 4.95 |
| 534.71 | 5.34 | 5.34 |
| 506.66 | 4.71 | 4.71 |
| 542.71 | 0.45 | 0.45 |
| 372.50 | 1.82 | 1.82 |
| 668.82 | 4.48 | 4.48 |
| 638.84 | 5.21 | 5.21 |
| 752.99 | 6.15 | 6.15 |
| 452.63 | 3.72 | 3.72 |
| 552.75 | 5.39 | 5.39 |
| 420.59 | 3.23 | 3.23 |
| 492.63 | 4.32 | 4.32 |
| 674.68 | 2.89 | 2.89 |
| 481.55 | 1.98 | 1.98 |
| 584.75 | 3.34 | 3.34 |
| 448.60 | 3.05 | 3.05 |
| 506.64 | 2.59 | 2.59 |
| 725.92 | 4.50 | 4.50 |
| 927.14 | 4.73 | 4.73 |
| 554.72 | 3.80 | 3.80 |
| 566.71 | 3.77 | 3.77 |
| 642.75 | 4.77 | 4.77 |
| 505.70 | 3.01 | 3.01 |
| 605.81 | 4.58 | 4.58 |
| 686.93 | 4.88 | 4.88 |
| 599.69 | 3.58 | 3.58 |
| 552.68 | 3.38 | 3.38 |
| 604.83 | 5.40 | 5.40 |
| 532.76 | 4.66 | 4.66 |
| 484.63 | 2.14 | 2.14 |
| 480.69 | 4.17 | 4.17 |
| 612.72 | 3.47 | 3.47 |
| 654.86 | 4.93 | 4.93 |
| 524.63 | 3.99 | 3.99 |
| 506.66 | 4.56 | 4.56 |
| 448.37 | 2.96 | 2.96 |
| 536.79 | 5.73 | 5.73 |
| 630.82 | 3.61 | 3.61 |
| 580.72 | 3.79 | 3.79 |
| 548.65 | 3.84 | 3.84 |
| 580.65 | 3.51 | 3.51 |
| 448.62 | 4.21 | 4.21 |
| 452.56 | 2.19 | 2.19 |
| 500.69 | 4.70 | 4.70 |
| 428.49 | 1.74 | 1.74 |
| 504.63 | 1.58 | 1.58 |
| 508.74 | 4.95 | 4.95 |
| 560.57 | 4.47 | 4.47 |
| 472.56 | 1.63 | 1.63 |
| 476.67 | 4.99 | 4.99 |
| 528.50 | 4.52 | 4.52 |
| 861.11 | 6.42 | 6.42 |
| 572.67 | 4.57 | 4.57 |
| 552.68 | 4.61 | 4.61 |
| 608.70 | 4.44 | 4.44 |
| 584.75 | 4.56 | 4.56 |
| 552.68 | 3.04 | 3.04 |
| 708.94 | 5.32 | 5.32 |
| 640.77 | 4.39 | 4.39 |
| 478.60 | 3.93 | 3.93 |
| 454.63 | 1.80 | 1.80 |
| 430.59 | 0.48 | 0.48 |
| 552.75 | 5.05 | 5.05 |
| 893.17 | 6.37 | 6.37 |
| 660.87 | 3.13 | 3.13 |
| 608.82 | 3.67 | 3.67 |
| 692.94 | 3.08 | 3.08 |
| 504.62 | 3.46 | 3.46 |
| 452.63 | 3.39 | 3.39 |
| 536.76 | 4.39 | 4.39 |
| 420.56 | 3.43 | 3.43 |
| 472.55 | 3.50 | 3.50 |
| 504.69 | 4.44 | 4.44 |
| 504.69 | 4.44 | 4.44 |
| 544.71 | 5.44 | 5.44 |
| 576.77 | 5.39 | 5.39 |
| 524.63 | 3.30 | 3.30 |
| 556.70 | 3.25 | 3.25 |
| 576.70 | 4.27 | 4.27 |
| 484.63 | 1.86 | 1.86 |
| 512.61 | 2.52 | 2.52 |
| 560.74 | 2.81 | 2.81 |
| 754.96 | 6.96 | 6.96 |
| 554.73 | 3.43 | 3.43 |
| 428.54 | 1.90 | 1.90 |
| 460.61 | 1.86 | 1.86 |
| 560.68 | 4.55 | 4.55 |
| 568.63 | 1.97 | 1.97 |
| 600.70 | 1.92 | 1.92 |
| 456.66 | 3.88 | 3.88 |
| 520.68 | 5.10 | 5.10 |
| 424.60 | 3.92 | 3.92 |
| 512.68 | 2.64 | 2.64 |
| 568.55 | 2.41 | 2.41 |
| 739.00 | 5.95 | 5.95 |
| 739.00 | 5.86 | 5.86 |
| 739.00 | 5.86 | 5.86 |
| 706.94 | 6.00 | 6.00 |
| 706.94 | 5.91 | 5.91 |
| 706.94 | 5.91 | 5.91 |
| 536.76 | 4.39 | 4.39 |
| 640.77 | 3.81 | 3.81 |
| 738.51 | 5.32 | 5.32 |
| 512.68 | 2.92 | 2.92 |
| 617.54 | 5.15 | 5.15 |
| 608.70 | 3.86 | 3.86 |
| 706.44 | 5.36 | 5.36 |
| 480.62 | 2.97 | 2.97 |
| 538.77 | 2.56 | 2.56 |
| 538.77 | 2.82 | 2.82 |
| 538.77 | 2.56 | 2.56 |
| 506.70 | 2.61 | 2.61 |
| 506.70 | 2.87 | 2.87 |
| 506.70 | 2.61 | 2.61 |
| 580.72 | 4.14 | 4.14 |
| 584.66 | 3.38 | 3.38 |
| 548.65 | 4.18 | 4.18 |
| 552.59 | 3.43 | 3.43 |
| 462.58 | -1.58 | -1.58 |
| 728.88 | 2.18 | 2.18 |
| 430.52 | -1.53 | -1.53 |
| 612.80 | 4.38 | 4.38 |
| 496.64 | 4.19 | 4.19 |
| 552.68 | 3.04 | 3.04 |
| 552.68 | 4.61 | 4.61 |
| 507.65 | 3.13 | 3.13 |
| 580.81 | 5.10 | 5.10 |
| 488.59 | -0.19 | -0.19 |
| 508.60 | 2.20 | 2.20 |
| 574.72 | 4.01 | 4.01 |
| 584.75 | 4.29 | 4.29 |
| 644.80 | 4.30 | 4.30 |
| 680.88 | 3.08 | 3.08 |
| 552.68 | 4.33 | 4.33 |
| 612.73 | 4.35 | 4.35 |
| 584.75 | 4.29 | 4.29 |
| 610.84 | 4.40 | 4.40 |
| 552.68 | 4.33 | 4.33 |
| 578.77 | 4.45 | 4.45 |
| 580.74 | 4.69 | 4.69 |
| 632.81 | 5.33 | 5.33 |
| 644.87 | 5.45 | 5.45 |
| 544.71 | 5.30 | 5.30 |
| 538.66 | 2.65 | 2.65 |
| 594.68 | 4.05 | 4.05 |
| 510.60 | 2.91 | 2.91 |
| 608.70 | 4.44 | 4.44 |
| 524.63 | 3.30 | 3.30 |
| 554.73 | 3.19 | 3.19 |
| 538.66 | 2.99 | 2.99 |
| 608.70 | 4.35 | 4.35 |
| 622.73 | 4.44 | 4.44 |
| 668.82 | 5.08 | 5.08 |
| 556.70 | 3.40 | 3.40 |
| 584.75 | 3.26 | 3.26 |
| 680.88 | 3.08 | 3.08 |
| 660.69 | 6.31 | 6.31 |
| 636.91 | 6.87 | 6.87 |
| 754.96 | 6.96 | 6.96 |
| 835.02 | 3.93 | 3.93 |
| 649.61 | 5.10 | 5.10 |
| 564.74 | 3.51 | 3.51 |
| 603.86 | 7.09 | 7.09 |
| 721.91 | 7.18 | 7.18 |
| 603.75 | 5.94 | 5.94 |
| 572.67 | 5.81 | 5.81 |
| 554.73 | 3.43 | 3.43 |
| 522.66 | 3.48 | 3.48 |
| 694.82 | 4.17 | 4.17 |
| 650.79 | 1.61 | 1.61 |
| 510.67 | 4.23 | 4.23 |
| 630.83 | 5.25 | 5.25 |
| 598.76 | 5.30 | 5.30 |
| 646.82 | 4.42 | 4.42 |
| 640.79 | 4.64 | 4.64 |
| 612.80 | 4.65 | 4.65 |
| 612.73 | 4.35 | 4.35 |
| 605.65 | 5.70 | 5.70 |
| 636.88 | 6.70 | 6.70 |
| 552.68 | 3.30 | 3.30 |
| 572.76 | 6.55 | 6.55 |
| 593.52 | 4.61 | 4.61 |
| 596.59 | 3.86 | 3.86 |
| 636.88 | 6.70 | 6.70 |
| 602.77 | 5.09 | 5.09 |
| 596.81 | 3.66 | 3.66 |
| 576.69 | 5.91 | 5.91 |
| 574.72 | 4.01 | 4.01 |
| 682.86 | 1.57 | 1.57 |
| 576.69 | 5.91 | 5.91 |
| 584.75 | 4.29 | 4.29 |
| 608.70 | 3.75 | 3.75 |
| 604.74 | 5.76 | 5.76 |
| 572.67 | 5.81 | 5.81 |
| 404.52 | 2.25 | 2.25 |
| 693.85 | 3.66 | 3.66 |
| 596.70 | 4.83 | 4.83 |
| 582.78 | 3.27 | 3.27 |
| 550.71 | 3.32 | 3.32 |
| 666.86 | 3.62 | 3.62 |
| 604.81 | 6.75 | 6.75 |
| 640.77 | 3.70 | 3.70 |
| 614.75 | 3.18 | 3.18 |
| 644.80 | 3.01 | 3.01 |
| 522.73 | 4.35 | 4.35 |
| 628.80 | 4.70 | 4.70 |
| 574.75 | 3.18 | 3.18 |
| 783.01 | 3.69 | 3.69 |
| 752.96 | 3.86 | 3.86 |
| 546.70 | 3.10 | 3.10 |
| 644.80 | 3.35 | 3.35 |
| 614.78 | 3.82 | 3.82 |
| 552.75 | 4.89 | 4.89 |
| 520.68 | 4.93 | 4.93 |
| 570.72 | 4.25 | 4.25 |
| 570.72 | 4.25 | 4.25 |
| 700.84 | 4.59 | 4.59 |
| 612.73 | 3.33 | 3.33 |
| 404.50 | -0.23 | -0.23 |
| 446.54 | 0.34 | 0.34 |
| 593.59 | 5.58 | 5.58 |
| 561.52 | 5.62 | 5.62 |
| 612.73 | 3.40 | 3.40 |
| 630.77 | 3.31 | 3.31 |
| 644.80 | 4.30 | 4.30 |
| 612.73 | 4.35 | 4.35 |
| 621.64 | 6.70 | 6.70 |
| 580.81 | 6.01 | 6.01 |
| 612.80 | 5.41 | 5.41 |
| 552.68 | 4.33 | 4.33 |
| 598.71 | 3.96 | 3.96 |
| 634.79 | 3.67 | 3.67 |
| 768.99 | 3.65 | 3.65 |
| 626.79 | 5.37 | 5.37 |
| 594.73 | 5.41 | 5.41 |
| 682.49 | 5.80 | 5.80 |
| 552.68 | 4.33 | 4.33 |
| 951.18 | 7.58 | 7.58 |
| 528.61 | 4.60 | 4.60 |
| 589.57 | 6.75 | 6.75 |
| 907.20 | 6.33 | 6.33 |
| 688.93 | 3.13 | 3.13 |
| 664.81 | 5.19 | 5.19 |
| 584.68 | 1.59 | 1.59 |
| 578.72 | 4.75 | 4.75 |
| 538.66 | 2.95 | 2.95 |
| 675.84 | 4.59 | 4.59 |
| 650.42 | 5.84 | 5.84 |
| 682.49 | 5.80 | 5.80 |
| 650.42 | 5.84 | 5.84 |
| 624.76 | 4.69 | 4.69 |
| 682.42 | 4.82 | 4.82 |
| 682.42 | 4.82 | 4.82 |
| 520.68 | 5.44 | 5.44 |
| 588.76 | 5.76 | 5.76 |
| 750.95 | 4.45 | 4.45 |
| 528.61 | 4.60 | 4.60 |
| 564.59 | 4.87 | 4.87 |
| 560.68 | 4.55 | 4.55 |
| 486.60 | 4.26 | 4.26 |
| 680.86 | 5.42 | 5.42 |
| 459.60 | 2.64 | 2.64 |
| 596.66 | 4.83 | 4.83 |
| 612.80 | 5.07 | 5.07 |
| 580.74 | 5.11 | 5.11 |
| 1043.24 | ||
| 774.97 | 4.49 | 4.49 |
| 564.59 | 5.42 | 5.42 |
| 590.78 | 5.61 | 5.61 |
| 480.57 | 4.19 | 4.19 |
| 593.52 | 4.61 | 4.61 |
| 494.61 | 3.11 | 3.11 |
| 526.67 | 3.06 | 3.06 |
| 493.62 | 3.71 | 3.71 |
| 493.62 | 3.71 | 3.71 |
| 494.61 | 3.11 | 3.11 |
| 646.80 | 6.44 | 6.44 |
| 608.70 | 3.57 | 3.57 |
| 516.63 | 3.79 | 3.79 |
| 502.60 | 3.75 | 3.75 |
| 522.66 | 3.85 | 3.85 |
| 532.63 | 3.76 | 3.76 |
| 537.05 | 4.40 | 4.40 |
| 616.68 | 2.73 | 2.73 |
| 584.68 | 3.32 | 3.32 |
| 446.56 | 2.46 | 2.46 |
| 570.70 | 5.28 | 5.28 |
| 750.95 | 6.37 | 6.37 |
| 550.71 | 3.23 | 3.23 |
| 704.88 | 7.67 | 7.67 |
| 722.89 | 7.01 | 7.01 |
| 704.88 | 7.67 | 7.67 |
| 522.66 | 3.48 | 3.48 |
| 622.78 | 5.90 | 5.90 |
| 680.81 | 7.93 | 7.93 |
| 875.86 | 5.15 | 5.15 |
| 522.66 | 3.81 | 3.81 |
| 643.77 | 4.02 | 4.02 |
| 521.05 | 4.91 | 4.91 |
| 537.05 | 4.61 | 4.61 |
| 502.60 | 3.96 | 3.96 |
| 592.73 | 5.83 | 5.83 |
| 615.76 | 5.28 | 5.28 |
| 515.64 | 3.71 | 3.71 |
| 368.47 | 2.66 | 2.66 |
| 575.09 | 5.12 | 5.12 |
| 561.06 | 4.82 | 4.82 |
| 544.61 | 4.30 | 4.30 |
| 543.07 | 4.46 | 4.46 |
| 525.69 | 3.67 | 3.67 |
| 368.47 | 2.66 | 2.66 |
| 502.60 | 3.75 | 3.75 |
| 538.58 | 4.03 | 4.03 |
| 501.62 | 4.40 | 4.40 |
| 516.63 | 4.26 | 4.26 |
| 487.59 | 3.65 | 3.65 |
| 487.59 | 3.65 | 3.65 |
| 432.55 | 3.04 | 3.04 |
| 330.46 | 1.45 | 1.45 |
| 734.69 | 4.88 | 4.88 |
| 525.69 | 3.67 | 3.67 |
| 555.71 | 3.67 | 3.67 |
| 526.67 | 3.06 | 3.06 |
| 504.64 | 4.17 | 4.17 |
| 652.81 | 4.81 | 4.81 |
| 624.76 | 4.69 | 4.69 |
| 502.60 | 3.75 | 3.75 |
| 537.05 | 4.40 | 4.40 |
| 516.63 | 4.26 | 4.26 |
| 615.76 | 5.28 | 5.28 |
| 515.64 | 3.71 | 3.71 |
| 474.61 | 4.34 | 4.34 |
| 494.60 | 4.75 | 4.75 |
| 545.12 | 4.88 | 4.88 |
| 511.66 | 3.62 | 3.62 |
| 508.63 | 4.88 | 4.88 |
| 621.79 | 5.34 | 5.34 |
| 561.11 | 4.37 | 4.37 |
| 526.67 | 3.72 | 3.72 |
| 639.83 | 3.94 | 3.94 |
| 552.66 | 4.44 | 4.44 |
| 580.72 | 4.81 | 4.81 |
| 615.76 | 3.97 | 3.97 |
| 587.71 | 4.50 | 4.50 |
| 487.59 | 3.65 | 3.65 |
| 587.71 | 4.50 | 4.50 |
| 474.59 | 4.24 | 4.24 |
| 502.60 | 4.82 | 4.82 |
| 432.53 | 3.31 | 3.31 |
| 474.61 | 4.48 | 4.48 |
| 522.66 | 3.23 | 3.23 |
| 446.56 | 3.70 | 3.70 |
| 460.49 | 3.38 | 3.38 |