Basic Information
ID: ALA3705633
Type: Binding
Description: Radioligand Binding Assay: The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing rhesus (Macacca Mulatta) H3 receptor. Additionally, the compounds of this invention have been demonstrated by GTPγS radioligand binding assay to inhibit rhesus H3 constitutive functional activity in cell membranes.
Activity Charts
Bioactivity
Activity Types for Assay ALA3705633
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 496.70 | 4.81 | 4.81 |
| 496.70 | 4.81 | 4.81 |
| 496.70 | 4.81 | 4.81 |
| 496.70 | 4.81 | 4.81 |
| 496.70 | 4.81 | 4.81 |
| 396.58 | 3.16 | 3.16 |
| 396.58 | 3.16 | 3.16 |
| 396.58 | 3.16 | 3.16 |
| 396.58 | 3.16 | 3.16 |
| 478.73 | 5.07 | 5.07 |
| 478.73 | 5.07 | 5.07 |
| 478.73 | 5.07 | 5.07 |
| 478.73 | 5.07 | 5.07 |
| 478.73 | 5.07 | 5.07 |
| 584.68 | 5.62 | 5.62 |
| 584.68 | 5.62 | 5.62 |
| 584.68 | 5.62 | 5.62 |
| 584.68 | 5.62 | 5.62 |
| 584.68 | 5.62 | 5.62 |
| 510.72 | 5.20 | 5.20 |
| 496.70 | 4.89 | 4.89 |
| 500.66 | 4.64 | 4.64 |
| 410.61 | 3.55 | 3.55 |
| 396.58 | 3.25 | 3.25 |
| 414.57 | 3.39 | 3.39 |
| 515.70 | 4.50 | 4.50 |
| 504.68 | 4.70 | 4.70 |
| 500.69 | 4.80 | 4.80 |
| 518.68 | 4.94 | 4.94 |
| 524.73 | 5.20 | 5.20 |
| 526.70 | 4.05 | 4.05 |
| 452.69 | 4.68 | 4.68 |
| 506.78 | 5.85 | 5.85 |
| 450.67 | 4.37 | 4.37 |
| 480.70 | 4.14 | 4.14 |
| 504.69 | 5.30 | 5.30 |
| 494.66 | 4.89 | 4.89 |
| 496.70 | 4.89 | 4.89 |
| 564.69 | 5.91 | 5.91 |
| 514.69 | 5.03 | 5.03 |
| 496.70 | 4.89 | 4.89 |
| 564.69 | 5.91 | 5.91 |
| 514.69 | 5.03 | 5.03 |
| 396.58 | 3.25 | 3.25 |
| 464.58 | 4.27 | 4.27 |
| 414.57 | 3.39 | 3.39 |
| 396.58 | 3.25 | 3.25 |
| 464.58 | 4.27 | 4.27 |
| 414.57 | 3.39 | 3.39 |
| 536.74 | 4.35 | 4.35 |
| 518.68 | 4.94 | 4.94 |
| 524.73 | 5.20 | 5.20 |
| 554.73 | 4.49 | 4.49 |
| 508.71 | 3.91 | 3.91 |
| 560.71 | 5.69 | 5.69 |
| 468.66 | 4.51 | 4.51 |
| 496.72 | 5.29 | 5.29 |
| 560.75 | 6.56 | 6.56 |
| 512.71 | 4.52 | 4.52 |
| 568.68 | 5.36 | 5.36 |
| 522.61 | 3.76 | 3.76 |
| 604.72 | 6.58 | 6.58 |
| 554.66 | 5.43 | 5.43 |
| 544.62 | 5.02 | 5.02 |
| 620.74 | 4.98 | 4.98 |
| 530.64 | 5.38 | 5.38 |
| 504.64 | 5.00 | 5.00 |
| 548.69 | 5.01 | 5.01 |
| 450.55 | 3.87 | 3.87 |