Basic Information
ID: ALA3705635
Type: Binding
Description: Enzyme Inhibition Assay: The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concentration-dependent mariner. Specifically, the enzyme activity of recombinant human GCase (rhGCase; Cerezyme, Genzyme Corp.) was measured using the 4-methylumbelliferyl-β-D-glucopyranoside (4-MU-β-D-Glc) fluorogenic substrate in the absence or in the presence of varying amounts of each test compound.
Format: BAO_0000357
Organism: Homo sapiens
Target: Beta-glucocerebrosidase(ALA2179)
Document: ALA3639164
BindingDB Source: 6104
Activity Charts
Bioactivity
Activity Types for Assay ALA3705635
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 167.16 | -0.81 | -0.81 |
| 163.19 | -0.71 | -0.71 |
| 161.20 | -1.69 | -1.69 |
| 207.27 | 0.17 | 0.17 |
| 223.27 | -0.34 | -0.34 |
| 175.23 | -1.30 | -1.30 |
| 177.22 | -0.32 | -0.32 |