Basic Information
ID: ALA3705652
Type: Binding
Description: Reductase Assay : The following procedure was followed using a HMG-CoA Reductase assay kit obtained from Sigma-Aldrich (catalogue number CS1090). The assay is based on the spectrophotometric measurement of the decrease in absorbance at 340 nm of NADPH in solution. A decrease in absorbance is caused by the oxidation of NADPH by the catalytic subunit of HMGR in the presence of the substrate HMG-CoA. Effective inhibition of the HMG-CoA leads to a reduction in oxidation of NADPH which in turn leads to a smaller reduction in the absorbance at 340 nm over time.
Format: BAO_0000357
Target: HMG-CoA reductase(ALA402)
Document: ALA3638401
BindingDB Source: 7100
Activity Charts
Bioactivity
Activity Types for Assay ALA3705652
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 481.55 | 2.40 | 2.40 |
| 611.78 | 6.72 | 6.72 |
| 595.74 | 6.11 | 6.11 |
| 687.06 | 7.29 | 7.29 |
| 569.70 | 5.55 | 5.55 |
| 596.94 | 5.07 | 5.07 |
| 601.70 | 4.78 | 4.78 |
| 584.67 | 4.59 | 4.59 |
| 597.75 | 6.33 | 6.33 |
| 612.72 | 5.37 | 5.37 |
| 507.63 | 4.11 | 4.11 |
| 595.62 | 5.18 | 5.18 |