Basic Information
ID: ALA3705662
Type: Binding
Description: Isothermal Titration Calorimetry Assays: Titrations were performed using a VP-ITC or ITC200 calorimeter from Microcal (Northampton, Mass.). BCL-XL was used at concentrations between 25 and 100 μM in 20 mM sodium phosphate buffer (pH 7.4) and 5-10% DMSO. Titrants were used at concentrations 10-15× of the protein in the same buffer. Titrations were carried out at 25° C. Data were analyzed using Microcal Origin software provided by the ITC manufacturer (Microcal, Northampton, Mass.).
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3705662
Kd
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 462.54 | 6.76 | 6.76 |
| 614.65 | 7.36 | 7.36 |
| 686.72 | 9.28 | 9.28 |
| 642.70 | 7.98 | 7.98 |