Basic Information
ID: ALA3705712
Type: Binding
Description: Inhibition Assay (Testosterone Hydroxylase): To gain insight into the selectivity of the synthetic compounds, nicotine, nicotine related alkaloids and nicotine metabolites for inhibition of other CYPs, we examined the major CYP present in human liver (i.e., CYP 3A4). That the CYP2A6 inhibitors showed low or no inhibitory activity against CYP3A4 suggests that the inhibitors examined selectively inhibited CYP2A6.
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3705712
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 162.24 | 1.85 | 1.85 |
| 161.23 | 2.81 | 2.81 |
| 145.16 | 1.47 | 1.47 |
| 179.22 | 2.95 | 2.95 |
| 175.26 | 3.12 | 3.12 |
| 193.25 | 3.26 | 3.26 |
| 170.22 | 2.45 | 2.45 |
| 157.18 | 1.54 | 1.54 |
| 159.19 | 1.58 | 1.58 |
| 145.16 | 1.27 | 1.27 |
| 189.24 | 2.62 | 2.62 |
| 203.27 | 3.01 | 3.01 |
| 190.27 | 2.27 | 2.27 |
| 174.20 | 1.80 | 1.80 |
| 132.17 | 0.39 | 0.39 |
| 175.26 | 3.12 | 3.12 |
| 193.25 | 3.26 | 3.26 |
| 159.19 | 1.48 | 1.48 |
| 176.24 | 2.39 | 2.39 |
| 178.24 | 1.26 | 1.26 |
| 188.19 | 2.61 | 2.61 |
| 204.25 | 3.08 | 3.08 |