Basic Information
ID: ALA3705718
Type: Binding
Description: Binding Assay: Binding assays were performed as described in Schaffhauser H, Richards J G, Cartmell J, Chaboz S, Kemp J A, Klingelschmidt A, Messer J, Stadler H, Woltering T and Mutel V (1998) In vitro binding characteristics of a new selective group II metabotropic glutamate receptor radioligand, [3H]LY354740, in rat brain. Mol Pharmacol 53:228-233) at room temperature with slight modifications.
Format: BAO_0000221
Organism: Rattus norvegicus
Tissue: Brain
Target: Metabotropic glutamate receptor 5(ALA2564)
Document: ALA3639017
BindingDB Source: 6107
Activity Charts
Bioactivity
Activity Types for Assay ALA3705718
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 214.29 | 2.55 | 2.55 |
| 226.30 | 2.89 | 2.89 |
| 294.35 | 4.05 | 4.05 |
| 319.36 | 3.92 | 3.92 |
| 294.35 | 4.05 | 4.05 |
| 294.35 | 4.05 | 4.05 |
| 301.37 | 3.79 | 3.79 |
| 290.39 | 4.22 | 4.22 |
| 324.38 | 4.06 | 4.06 |
| 310.81 | 4.57 | 4.57 |
| 306.39 | 3.92 | 3.92 |
| 308.38 | 4.36 | 4.36 |
| 291.38 | 3.62 | 3.62 |
| 323.45 | 4.03 | 4.03 |
| 311.80 | 3.96 | 3.96 |
| 305.41 | 3.93 | 3.93 |
| 316.39 | 3.59 | 3.59 |
| 316.39 | 3.59 | 3.59 |
| 283.40 | 3.24 | 3.24 |
| 283.40 | 3.24 | 3.24 |
| 284.39 | 2.63 | 2.63 |
| 272.38 | 2.85 | 2.85 |
| 298.42 | 2.88 | 2.88 |
| 284.39 | 2.63 | 2.63 |
| 259.33 | 2.43 | 2.43 |
| 258.35 | 3.03 | 3.03 |
| 272.37 | 3.42 | 3.42 |
| 288.44 | 4.14 | 4.14 |
| 289.43 | 3.53 | 3.53 |
| 282.41 | 4.29 | 4.29 |
| 256.37 | 3.54 | 3.54 |
| 283.40 | 3.69 | 3.69 |
| 312.34 | 4.19 | 4.19 |
| 315.40 | 4.09 | 4.09 |
| 327.41 | 4.46 | 4.46 |
| 304.42 | 4.53 | 4.53 |
| 331.40 | 3.79 | 3.79 |
| 304.42 | 4.53 | 4.53 |
| 315.40 | 4.19 | 4.19 |
| 301.44 | 2.80 | 2.80 |
| 292.37 | 3.38 | 3.38 |
| 269.37 | 3.21 | 3.21 |
| 310.81 | 4.57 | 4.57 |
| 306.39 | 3.41 | 3.41 |
| 312.34 | 4.19 | 4.19 |
| 320.42 | 4.23 | 4.23 |
| 319.36 | 3.92 | 3.92 |
| 308.38 | 4.36 | 4.36 |
| 306.39 | 3.41 | 3.41 |
| 324.38 | 4.06 | 4.06 |
| 290.39 | 4.22 | 4.22 |
| 295.41 | 3.38 | 3.38 |
| 308.38 | 4.36 | 4.36 |
| 304.42 | 4.48 | 4.48 |
| 306.39 | 3.41 | 3.41 |
| 297.43 | 3.63 | 3.63 |
| 297.43 | 3.62 | 3.62 |
| 285.42 | 3.85 | 3.85 |
| 324.84 | 4.88 | 4.88 |
| 301.39 | 3.18 | 3.18 |
| 271.39 | 3.46 | 3.46 |
| 304.42 | 4.53 | 4.53 |
| 322.46 | 4.64 | 4.64 |
| 306.39 | 3.41 | 3.41 |
| 285.42 | 3.85 | 3.85 |
| 304.42 | 4.03 | 4.03 |
| 271.39 | 3.46 | 3.46 |
| 269.37 | 2.85 | 2.85 |
| 301.37 | 3.79 | 3.79 |
| 320.42 | 4.06 | 4.06 |
| 271.39 | 3.46 | 3.46 |
| 294.42 | 4.15 | 4.15 |
| 295.41 | 3.24 | 3.24 |
| 268.38 | 3.90 | 3.90 |
| 240.33 | 3.12 | 3.12 |
| 344.36 | 4.93 | 4.93 |
| 292.36 | 4.04 | 4.04 |
| 297.43 | 3.48 | 3.48 |
| 306.39 | 3.41 | 3.41 |
| 288.44 | 4.14 | 4.14 |
| 306.39 | 3.41 | 3.41 |
| 301.37 | 3.79 | 3.79 |
| 271.39 | 3.09 | 3.09 |
| 301.39 | 3.18 | 3.18 |
| 320.42 | 4.31 | 4.31 |
| 234.71 | 2.90 | 2.90 |
| 293.35 | 3.43 | 3.43 |
| 314.41 | 1.85 | 1.85 |
| 298.42 | 3.02 | 3.02 |
| 272.38 | 2.85 | 2.85 |
| 321.41 | 3.78 | 3.78 |
| 298.42 | 3.02 | 3.02 |
| 270.36 | 2.24 | 2.24 |
| 272.38 | 2.49 | 2.49 |
| 302.43 | 2.19 | 2.19 |
| 400.50 | 3.42 | 3.42 |
| 284.39 | 3.00 | 3.00 |
| 268.35 | 2.02 | 2.02 |
| 295.34 | 3.45 | 3.45 |
| 318.38 | 2.35 | 2.35 |