Basic Information
ID: ALA3705843
Type: Binding
Description: Inhibition Assay: Previously, one of the following compounds discussed below have been studied in memapsin 2 inhibition (Ghosh et al., 2008), which the others are previously unpublished. Given the closely related substrate specificity for memapsin 1 and memapsin 2, the inventors chose to screen these previously identified memapsin 2 inhibitors for lead compounds as memapsin 1 inhibitors. Recombinant memapsin 1 ectodomain was prepared as described by Turner et al. (2002) and assayed using a commercially purchased fluorescent substrate.
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3705843
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 638.84 | 3.90 | 3.90 |
| 654.76 | 5.03 | 5.03 |
| 602.78 | 3.33 | 3.33 |
| 630.83 | 4.11 | 4.11 |
| 596.77 | 2.49 | 2.49 |
| 610.80 | 2.80 | 2.80 |
| 698.81 | 5.21 | 5.21 |
| 585.79 | 6.41 | 6.41 |
| 649.86 | 3.21 | 3.21 |
| 587.78 | 0.25 | 0.25 |
| 537.66 | 4.02 | 4.02 |
| 619.78 | -1.07 | -1.07 |
| 599.85 | 8.10 | 8.10 |
| 583.78 | 7.63 | 7.63 |
| 643.81 | 5.09 | 5.09 |
| 644.86 | 4.42 | 4.42 |
| 695.88 | 2.39 | 2.39 |
| 616.80 | 3.64 | 3.64 |
| 821.78 | 2.99 | 2.99 |
| 408.55 | 4.43 | 4.43 |
| 702.87 | 4.00 | 4.00 |
| 652.86 | 4.15 | 4.15 |