Basic Information
ID: ALA3705966
Type: Binding
Description: Radioligand Binding Assay: Compound potency can be assessed by a radioligand binding assay (described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430) in which the inhibition constant (Ki) is determined in membranes prepared from CHO cells expressing either the orexin-1 (OX1) or orexin-2 (OX2) receptor.
Organism: Rattus norvegicus
Cell type: CHO
Activity Charts
Bioactivity
Activity Types for Assay ALA3705966
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 422.50 | 4.34 | 4.34 |
| 436.53 | 4.73 | 4.73 |
| 422.50 | 4.42 | 4.42 |
| 423.49 | 3.82 | 3.82 |
| 409.47 | 3.51 | 3.51 |
| 452.60 | 6.28 | 6.28 |
| 447.55 | 5.61 | 5.61 |
| 423.49 | 4.89 | 4.89 |
| 439.56 | 5.36 | 5.36 |
| 434.52 | 4.70 | 4.70 |
| 438.50 | 3.58 | 3.58 |
| 424.48 | 3.27 | 3.27 |