Basic Information
ID: ALA3706032
Type: Binding
Description: Binding Assay: The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a recombinant human His-tagged MDM2 protein (residues 1-118) and a fluorescently tagged p53-based peptide. The design of the fluorescence probe was based upon a previously reported high-affinity p53-based peptidomimetic compound called PMDM6-F (García-Echeverria et al., J. Med. Chem. 43: 3205-3208 (2000)).
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3706032
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 563.50 | 4.09 | 4.09 |
| 575.51 | 4.23 | 4.23 |
| 611.49 | 4.47 | 4.47 |
| 611.49 | 4.47 | 4.47 |
| 577.48 | 3.08 | 3.08 |
| 477.37 | 2.95 | 2.95 |
| 477.37 | 2.95 | 2.95 |
| 491.39 | 3.29 | 3.29 |
| 491.39 | 3.29 | 3.29 |
| 519.40 | 3.21 | 3.21 |
| 519.40 | 3.21 | 3.21 |
| 568.50 | 3.94 | 3.94 |
| 476.38 | 4.53 | 4.53 |
| 651.63 | 4.41 | 4.41 |
| 463.34 | 4.87 | 4.87 |
| 548.44 | 4.76 | 4.76 |
| 596.49 | 5.80 | 5.80 |
| 540.44 | 3.86 | 3.86 |
| 612.49 | 6.13 | 6.13 |
| 544.42 | 3.61 | 3.61 |
| 560.48 | 4.63 | 4.63 |
| 561.47 | 4.02 | 4.02 |
| 583.45 | 5.51 | 5.51 |
| 603.52 | 4.45 | 4.45 |
| 559.47 | 4.13 | 4.13 |
| 561.44 | 4.26 | 4.26 |
| 543.50 | 4.46 | 4.46 |
| 582.46 | 6.12 | 6.12 |
| 546.47 | 4.81 | 4.81 |
| 492.38 | 3.50 | 3.50 |
| 588.51 | 5.54 | 5.54 |
| 596.48 | 5.45 | 5.45 |
| 562.47 | 4.05 | 4.05 |
| 546.47 | 4.81 | 4.81 |
| 602.53 | 5.79 | 5.79 |
| 562.47 | 4.05 | 4.05 |
| 520.43 | 4.28 | 4.28 |
| 574.52 | 5.59 | 5.59 |
| 560.50 | 5.20 | 5.20 |