Basic Information
ID: ALA3706043
Type: Binding
Description: Receptor Binding Assay: Using cytosol from progesterone receptor-expressing insect cells (Hi5), competitive binding to the progesterone receptor was determined from the ability to displace 3H-progesterone as reference substance from the receptor. If a compound has an affinity corresponding to progesterone, this corresponds to a competition factor (CF) of 1. CF values greater than 1 are characterized by a lower affinity for the progesterone receptor, and CF values of less than 1 are characterized by higher affinity. The test was carried out as test above, with the following modifications: cytosol from mineralocorticoid receptor-expressing insect cells (Hi5) was used, and the reference substance was 3H-aldosterone.
Format: BAO_0000019
Organism: Homo sapiens
Target: Mineralocorticoid receptor(ALA1994)
Document: ALA3638672
BindingDB Source: 6912
Activity Charts
Bioactivity
Activity Types for Assay ALA3706043
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 312.45 | 4.45 | 4.45 |
| 310.44 | 4.23 | 4.23 |
| 326.48 | 4.70 | 4.70 |
| 340.51 | 5.09 | 5.09 |
| 338.49 | 4.87 | 4.87 |
| 338.49 | 4.84 | 4.84 |
| 326.48 | 4.84 | 4.84 |
| 324.46 | 4.62 | 4.62 |
| 340.51 | 5.09 | 5.09 |
| 354.53 | 5.48 | 5.48 |
| 356.51 | 4.06 | 4.06 |
| 366.50 | 4.31 | 4.31 |