Basic Information
ID: ALA3706279
Type: Binding
Description: Inhibitory Assay: FCPIA Characterization of RGS Inhibitory Activity: CCG-50014 (FIG. 1) was originally identified as a potential inhibitor of RGS8 and RGS16 in a polyplex high throughput screen to identify inhibitors of the RGS-Gα interaction [4]. This activity was confirmed by analyzing the effect of CCG-50014 on several different RGS proteins with freshly reordered compound using multiplexed FCPIA. CCG-50014 fully inhibited several different RGS proteins including RGS4, 8, 16, and 19, but did not have activity on RGS7 or a mutated form of RGS4 that lacks cysteine residues.
Activity Charts
Bioactivity
Activity Types for Assay ALA3706279
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 316.36 | 2.56 | 2.56 |
| 294.35 | 3.27 | 3.27 |
| 277.32 | 2.95 | 2.95 |
| 266.09 | 1.83 | 1.83 |