Basic Information
ID: ALA3706302
Type: Binding
Description: ADP Glo Assay: The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds are mixed in buffer (50 mM TRIS pH 7.5, 20 mM MgCl2, 0.02% TX-100, 1 mM DTT, 0.2% (v/v) glycerol) and incubated at 37 C. for 15 minutes. The reaction is terminated and the level of product generated is measured using the ADP Glo Assay Kit (Promega, Madison Wis.).
Format: BAO_0000357
Target: Transitional endoplasmic reticulum ATPase(ALA1075145)
Document: ALA3638398
BindingDB Source: 6978
Activity Charts
Bioactivity
Activity Types for Assay ALA3706302
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 373.46 | 4.36 | 4.36 |
| 386.50 | 5.49 | 5.49 |
| 355.44 | 4.84 | 4.84 |
| 369.47 | 5.04 | 5.04 |
| 335.45 | 4.84 | 4.84 |
| 398.47 | 4.78 | 4.78 |
| 414.44 | 4.31 | 4.31 |
| 395.47 | 4.90 | 4.90 |
| 381.44 | 4.59 | 4.59 |
| 411.47 | 4.60 | 4.60 |
| 357.42 | 4.39 | 4.39 |
| 403.47 | 3.63 | 3.63 |
| 425.50 | 3.50 | 3.50 |
| 440.51 | 4.19 | 4.19 |
| 439.48 | 3.03 | 3.03 |
| 410.48 | 4.31 | 4.31 |
| 393.49 | 4.95 | 4.95 |
| 423.52 | 4.22 | 4.22 |
| 408.58 | 5.62 | 5.62 |
| 388.46 | 4.05 | 4.05 |
| 356.39 | 2.89 | 2.89 |
| 356.43 | 3.50 | 3.50 |
| 374.45 | 3.46 | 3.46 |
| 346.39 | 3.72 | 3.72 |
| 410.48 | 4.63 | 4.63 |
| 424.51 | 4.66 | 4.66 |
| 438.49 | 4.55 | 4.55 |
| 395.47 | 4.98 | 4.98 |
| 396.49 | 5.33 | 5.33 |
| 399.45 | 4.47 | 4.47 |
| 396.45 | 4.47 | 4.47 |
| 386.42 | 3.76 | 3.76 |
| 386.42 | 3.76 | 3.76 |
| 397.44 | 3.88 | 3.88 |
| 411.47 | 3.89 | 3.89 |
| 416.51 | 4.11 | 4.11 |
| 394.48 | 5.50 | 5.50 |
| 369.47 | 5.40 | 5.40 |
| 382.47 | 4.44 | 4.44 |
| 382.47 | 4.81 | 4.81 |
| 428.47 | 5.21 | 5.21 |
| 386.46 | 3.08 | 3.08 |
| 369.47 | 3.99 | 3.99 |
| 369.47 | 3.99 | 3.99 |
| 400.44 | 2.72 | 2.72 |
| 355.45 | 3.94 | 3.94 |
| 396.49 | 4.79 | 4.79 |
| 408.51 | 5.76 | 5.76 |
| 410.48 | 5.20 | 5.20 |
| 409.49 | 4.65 | 4.65 |
| 380.45 | 5.19 | 5.19 |
| 394.48 | 5.50 | 5.50 |
| 395.46 | 5.97 | 5.97 |
| 407.48 | 4.59 | 4.59 |
| 356.43 | 4.37 | 4.37 |
| 389.46 | 5.37 | 5.37 |
| 469.59 | 5.63 | 5.63 |
| 397.48 | 4.20 | 4.20 |
| 411.51 | 4.25 | 4.25 |
| 410.52 | 4.54 | 4.54 |
| 499.57 | 4.97 | 4.97 |
| 368.48 | 5.22 | 5.22 |
| 382.51 | 5.47 | 5.47 |
| 383.50 | 4.37 | 4.37 |
| 397.53 | 4.93 | 4.93 |
| 455.52 | 4.33 | 4.33 |
| 455.52 | 4.61 | 4.61 |
| 451.53 | 4.83 | 4.83 |
| 463.54 | 5.00 | 5.00 |
| 409.49 | 5.15 | 5.15 |
| 384.48 | 4.92 | 4.92 |
| 384.48 | 4.40 | 4.40 |
| 398.51 | 5.06 | 5.06 |
| 411.55 | 4.97 | 4.97 |
| 425.54 | 4.55 | 4.55 |
| 426.52 | 4.08 | 4.08 |
| 441.54 | 4.77 | 4.77 |
| 461.59 | 3.96 | 3.96 |
| 425.54 | 4.19 | 4.19 |
| 412.54 | 3.87 | 3.87 |
| 442.52 | 3.62 | 3.62 |
| 426.52 | 3.53 | 3.53 |
| 462.58 | 2.81 | 2.81 |
| 441.58 | 3.07 | 3.07 |
| 455.57 | 2.60 | 2.60 |
| 431.50 | 5.73 | 5.73 |
| 474.52 | 4.59 | 4.59 |
| 484.58 | 5.21 | 5.21 |