Basic Information
ID: ALA3706360
Type: Binding
Description: Receptor Binding Assay: Human monocytic cell line THP-1 cells were obtained from American Type Culture Collection (Manassas, Va., USA). The THP-1 cells were grown in RPMI-1640 (RPMI: Roswell Park Memorial Institute Medium-cell culture growth media) supplemented with 10% fetal bovine serum in a humidified 5% CO2 atmosphere at 37° C. The cell density was maintained between 0.5×106 cells/mL.
Cell type: THP-1
Activity Charts
Bioactivity
Activity Types for Assay ALA3706360
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 483.54 | 4.59 | 4.59 |
| 499.54 | 3.69 | 3.69 |
| 506.55 | 3.15 | 3.15 |
| 506.55 | 3.15 | 3.15 |
| 573.56 | 4.77 | 4.77 |
| 530.58 | 3.62 | 3.62 |
| 507.56 | 2.87 | 2.87 |
| 521.59 | 3.13 | 3.13 |
| 535.62 | 3.47 | 3.47 |
| 522.57 | 3.55 | 3.55 |
| 506.55 | 3.15 | 3.15 |
| 506.55 | 3.15 | 3.15 |
| 506.55 | 3.15 | 3.15 |
| 465.52 | 3.19 | 3.19 |
| 465.52 | 3.19 | 3.19 |
| 465.52 | 3.19 | 3.19 |
| 479.55 | 3.44 | 3.44 |
| 479.55 | 3.44 | 3.44 |
| 479.55 | 3.44 | 3.44 |
| 506.55 | 3.15 | 3.15 |
| 530.58 | 4.30 | 4.30 |
| 505.57 | 3.75 | 3.75 |
| 464.53 | 3.80 | 3.80 |
| 478.56 | 4.04 | 4.04 |
| 514.54 | 4.43 | 4.43 |
| 477.53 | 3.19 | 3.19 |
| 479.55 | 3.44 | 3.44 |
| 477.53 | 3.19 | 3.19 |
| 500.53 | 3.69 | 3.69 |
| 489.54 | 3.76 | 3.76 |
| 479.55 | 3.44 | 3.44 |
| 433.48 | 3.61 | 3.61 |
| 475.52 | 3.37 | 3.37 |
| 502.54 | 2.86 | 2.86 |
| 490.53 | 2.70 | 2.70 |
| 504.56 | 3.09 | 3.09 |
| 491.56 | 3.99 | 3.99 |
| 477.53 | 3.60 | 3.60 |
| 492.50 | 2.53 | 2.53 |
| 506.53 | 2.92 | 2.92 |
| 497.59 | 3.14 | 3.14 |
| 492.51 | 3.09 | 3.09 |
| 481.52 | 2.43 | 2.43 |
| 513.59 | 2.16 | 2.16 |
| 492.50 | 2.53 | 2.53 |
| 494.56 | 2.34 | 2.34 |
| 573.56 | 4.77 | 4.77 |
| 532.53 | 4.81 | 4.81 |
| 517.60 | 4.30 | 4.30 |
| 521.63 | 4.75 | 4.75 |
| 475.56 | 4.61 | 4.61 |
| 505.46 | 3.34 | 3.34 |
| 605.48 | 4.61 | 4.61 |
| 447.51 | 4.00 | 4.00 |
| 463.50 | 3.11 | 3.11 |
| 491.56 | 3.85 | 3.85 |
| 504.56 | 3.04 | 3.04 |
| 490.53 | 2.79 | 2.79 |
| 464.49 | 2.31 | 2.31 |
| 570.62 | 4.44 | 4.44 |
| 506.57 | 3.29 | 3.29 |
| 436.48 | 2.39 | 2.39 |
| 478.52 | 2.65 | 2.65 |
| 492.55 | 3.04 | 3.04 |
| 506.57 | 3.43 | 3.43 |
| 584.64 | 4.83 | 4.83 |
| 514.57 | 2.06 | 2.06 |
| 492.55 | 3.04 | 3.04 |
| 492.55 | 3.04 | 3.04 |
| 492.55 | 3.20 | 3.20 |
| 478.52 | 2.81 | 2.81 |
| 518.58 | 3.43 | 3.43 |
| 500.53 | 3.21 | 3.21 |
| 504.56 | 3.18 | 3.18 |
| 504.51 | 2.32 | 2.32 |
| 499.54 | 3.81 | 3.81 |
| 567.53 | 4.83 | 4.83 |
| 524.55 | 3.68 | 3.68 |
| 548.59 | 2.85 | 2.85 |
| 639.70 | 5.48 | 5.48 |
| 484.53 | 3.98 | 3.98 |
| 484.53 | 3.98 | 3.98 |
| 500.53 | 3.69 | 3.69 |
| 514.55 | 3.99 | 3.99 |
| 499.54 | 4.29 | 4.29 |
| 499.54 | 3.56 | 3.56 |
| 508.55 | 4.46 | 4.46 |
| 513.57 | 4.02 | 4.02 |
| 514.55 | 3.39 | 3.39 |
| 530.55 | 3.09 | 3.09 |
| 530.55 | 3.09 | 3.09 |
| 520.58 | 3.46 | 3.46 |
| 548.64 | 4.27 | 4.27 |
| 506.55 | 3.15 | 3.15 |
| 479.55 | 3.58 | 3.58 |
| 477.53 | 3.36 | 3.36 |
| 463.50 | 2.97 | 2.97 |
| 465.52 | 3.19 | 3.19 |
| 505.59 | 3.97 | 3.97 |
| 461.49 | 2.41 | 2.41 |
| 477.53 | 3.36 | 3.36 |
| 451.49 | 2.80 | 2.80 |
| 493.57 | 3.83 | 3.83 |
| 520.58 | 3.61 | 3.61 |
| 507.56 | 3.76 | 3.76 |
| 407.44 | 3.19 | 3.19 |
| 489.59 | 5.00 | 5.00 |
| 421.42 | 2.37 | 2.37 |
| 465.52 | 3.46 | 3.46 |
| 479.50 | 2.98 | 2.98 |
| 451.49 | 2.80 | 2.80 |
| 437.47 | 2.41 | 2.41 |
| 423.44 | 2.16 | 2.16 |
| 478.52 | 2.56 | 2.56 |
| 532.49 | 3.10 | 3.10 |
| 536.60 | 3.94 | 3.94 |
| 506.57 | 3.19 | 3.19 |
| 520.60 | 3.68 | 3.68 |
| 436.48 | 2.38 | 2.38 |
| 449.52 | 4.08 | 4.08 |
| 421.47 | 3.44 | 3.44 |
| 479.55 | 3.84 | 3.84 |
| 465.52 | 3.46 | 3.46 |
| 493.53 | 3.37 | 3.37 |
| 475.44 | 3.98 | 3.98 |
| 508.55 | 3.12 | 3.12 |
| 522.57 | 3.70 | 3.70 |
| 494.52 | 2.44 | 2.44 |
| 478.52 | 2.56 | 2.56 |
| 600.64 | 3.75 | 3.75 |
| 560.54 | 3.88 | 3.88 |
| 464.54 | 3.16 | 3.16 |
| 492.59 | 3.76 | 3.76 |
| 506.57 | 3.33 | 3.33 |
| 542.63 | 2.75 | 2.75 |
| 596.60 | 3.64 | 3.64 |
| 489.54 | 3.50 | 3.50 |
| 548.64 | 4.27 | 4.27 |
| 520.58 | 3.17 | 3.17 |
| 513.56 | 4.08 | 4.08 |
| 493.57 | 3.97 | 3.97 |
| 492.55 | 2.50 | 2.50 |
| 499.54 | 3.56 | 3.56 |
| 512.53 | 3.51 | 3.51 |
| 540.61 | 1.90 | 1.90 |
| 505.57 | 3.75 | 3.75 |
| 465.52 | 3.19 | 3.19 |
| 478.52 | 2.51 | 2.51 |
| 504.56 | 3.04 | 3.04 |
| 508.61 | 3.22 | 3.22 |
| 520.58 | 3.46 | 3.46 |
| 574.55 | 4.17 | 4.17 |
| 505.57 | 3.75 | 3.75 |
| 445.56 | 4.17 | 4.17 |