Basic Information
ID: ALA3707552
Type: Binding
Description: Inhibition Assay: Previously, one of the following compounds discussed below have been studied in memapsin 2 inhibition (Ghosh et al., 2008), which the others are previously unpublished. Given the closely related substrate specificity for memapsin 1 and memapsin 2, the inventors chose to screen these previously identified memapsin 2 inhibitors for lead compounds as memapsin 1 inhibitors. Recombinant memapsin 1 ectodomain was prepared as described by Turner et al. (2002) and assayed using a commercially purchased fluorescent substrate.
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3707552
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 602.78 | 3.33 | 3.33 |
| 630.83 | 4.11 | 4.11 |
| 596.77 | 2.49 | 2.49 |
| 610.80 | 2.80 | 2.80 |
| 644.86 | 4.42 | 4.42 |
| 616.80 | 3.64 | 3.64 |