Basic Information
ID: ALA3707738
Type: Binding
Description: Activity Assay: The invention also provide methods for assaying for epoxide hydrolase activity as diagnostic assay to identify individuals at increased risk for hypertension and/or those that would benefit from the therapeutic methods of the invention. Any of a number of standard assays for determining epoxide hydrolase activity can be used. For example, suitable assays are described in Gill, et al., Anal Biochem 131, 273-282 (1983); and Borhan, et al., Analytical Biochemistry 231, 188-200 (1995)). Suitable in vitro assays are described in Zeldin et al. J Biol. Chem. 268:6402-6407 (1993). Suitable in vivo assays are described in Zeldin et al. Arch Biochem Biophys 330:87-96 (1996). Assays for epoxide hydrolase using both putative natural substrates and surrogate substrates have been reviewed (see, Hammock, et al. In: Methods in Enzymology, Volume III, Steroids and Isoprenoids, Part B, (Law, J. H. and H. C. Rilling, eds. 1985), Academic Press, Orlando, Fla., pp. 303-311).
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3707738
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 350.03 | 5.94 | 5.94 |
| 234.30 | 2.85 | 2.85 |
| 254.42 | 3.83 | 3.83 |
| 252.74 | 3.79 | 3.79 |
| 282.47 | 4.76 | 4.76 |
| 269.34 | 4.26 | 4.26 |
| 206.33 | 3.83 | 3.83 |
| 246.35 | 2.86 | 2.86 |
| 252.74 | 3.79 | 3.79 |
| 248.33 | 3.15 | 3.15 |
| 218.30 | 3.14 | 3.14 |
| 276.42 | 3.59 | 3.59 |
| 224.35 | 2.95 | 2.95 |
| 315.59 | 5.29 | 5.29 |
| 344.20 | 3.75 | 3.75 |
| 260.38 | 3.25 | 3.25 |
| 252.40 | 3.73 | 3.73 |
| 260.38 | 4.26 | 4.26 |
| 232.33 | 2.82 | 2.82 |
| 254.33 | 3.44 | 3.44 |
| 269.39 | 1.34 | 1.34 |
| 220.32 | 3.39 | 3.39 |
| 250.39 | 3.51 | 3.51 |
| 233.31 | 2.72 | 2.72 |
| 233.31 | 2.21 | 2.21 |
| 306.41 | 2.88 | 2.88 |
| 236.29 | 3.28 | 3.28 |
| 276.42 | 3.44 | 3.44 |
| 268.36 | 4.29 | 4.29 |
| 224.26 | 3.01 | 3.01 |
| 312.46 | 3.89 | 3.89 |
| 274.41 | 4.51 | 4.51 |
| 266.77 | 4.04 | 4.04 |
| 274.41 | 4.44 | 4.44 |
| 302.30 | 4.04 | 4.04 |
| 302.46 | 5.26 | 5.26 |
| 310.40 | 4.93 | 4.93 |
| 328.50 | 4.22 | 4.22 |
| 187.28 | 2.70 | 2.70 |
| 215.34 | 3.48 | 3.48 |
| 225.33 | 3.38 | 3.38 |
| 249.31 | 2.60 | 2.60 |
| 281.44 | 4.51 | 4.51 |
| 281.44 | 4.80 | 4.80 |
| 211.30 | 3.01 | 3.01 |
| 320.39 | 3.98 | 3.98 |
| 309.41 | 4.91 | 4.91 |
| 277.41 | 3.87 | 3.87 |
| 281.44 | 4.51 | 4.51 |
| 283.37 | 4.40 | 4.40 |
| 333.43 | 5.55 | 5.55 |
| 171.24 | 2.07 | 2.07 |
| 223.36 | 3.41 | 3.41 |
| 223.36 | 3.26 | 3.26 |
| 259.39 | 3.85 | 3.85 |
| 268.44 | 4.37 | 4.37 |
| 306.49 | 4.33 | 4.33 |
| 270.38 | 4.54 | 4.54 |
| 254.76 | 4.04 | 4.04 |
| 214.35 | 3.06 | 3.06 |
| 242.41 | 3.84 | 3.84 |
| 214.35 | 3.05 | 3.05 |
| 256.43 | 4.23 | 4.23 |
| 226.36 | 3.20 | 3.20 |
| 254.42 | 3.98 | 3.98 |
| 248.37 | 4.17 | 4.17 |
| 282.82 | 4.82 | 4.82 |
| 276.42 | 4.95 | 4.95 |
| 310.87 | 5.60 | 5.60 |
| 270.46 | 4.62 | 4.62 |
| 284.49 | 4.86 | 4.86 |
| 298.52 | 5.40 | 5.40 |
| 284.49 | 5.01 | 5.01 |
| 282.47 | 4.76 | 4.76 |
| 198.31 | 2.42 | 2.42 |
| 198.31 | 2.27 | 2.27 |
| 285.39 | 2.14 | 2.14 |
| 212.34 | 2.81 | 2.81 |
| 226.36 | 3.20 | 3.20 |
| 242.36 | 2.17 | 2.17 |
| 240.39 | 3.59 | 3.59 |
| 268.44 | 4.37 | 4.37 |
| 310.53 | 5.54 | 5.54 |
| 340.51 | 4.60 | 4.60 |
| 324.55 | 5.93 | 5.93 |
| 338.58 | 6.32 | 6.32 |
| 210.32 | 2.56 | 2.56 |
| 238.38 | 3.20 | 3.20 |
| 238.38 | 3.20 | 3.20 |
| 238.38 | 3.20 | 3.20 |
| 252.40 | 3.59 | 3.59 |
| 236.32 | 1.58 | 1.58 |
| 210.24 | 0.65 | 0.65 |
| 261.37 | 2.73 | 2.73 |
| 280.46 | 4.22 | 4.22 |
| 238.38 | 3.34 | 3.34 |
| 308.51 | 5.29 | 5.29 |
| 236.36 | 2.81 | 2.81 |
| 304.48 | 4.08 | 4.08 |
| 246.35 | 3.76 | 3.76 |
| 246.35 | 3.38 | 3.38 |
| 246.35 | 3.38 | 3.38 |
| 290.45 | 3.83 | 3.83 |
| 232.33 | 3.39 | 3.39 |
| 274.41 | 3.64 | 3.64 |
| 219.29 | 2.54 | 2.54 |
| 272.39 | 3.70 | 3.70 |
| 319.41 | 4.84 | 4.84 |
| 282.39 | 4.54 | 4.54 |
| 232.33 | 3.45 | 3.45 |
| 243.31 | 3.01 | 3.01 |
| 260.34 | 3.34 | 3.34 |
| 266.77 | 3.47 | 3.47 |
| 280.80 | 3.51 | 3.51 |
| 297.20 | 3.90 | 3.90 |
| 247.34 | 2.40 | 2.40 |
| 261.37 | 3.21 | 3.21 |
| 263.30 | 3.05 | 3.05 |
| 277.32 | 2.73 | 2.73 |
| 360.59 | 5.93 | 5.93 |
| 254.33 | 2.73 | 2.73 |
| 258.37 | 3.38 | 3.38 |
| 294.40 | 3.33 | 3.33 |
| 282.39 | 4.17 | 4.17 |
| 262.40 | 4.51 | 4.51 |
| 314.81 | 3.64 | 3.64 |
| 228.29 | 3.37 | 3.37 |
| 384.52 | 5.95 | 5.95 |
| 280.76 | 3.11 | 3.11 |
| 226.28 | 2.86 | 2.86 |
| 239.27 | 3.63 | 3.63 |
| 244.32 | 2.89 | 2.89 |
| 240.30 | 3.51 | 3.51 |
| 244.26 | 3.00 | 3.00 |
| 302.37 | 4.53 | 4.53 |
| 315.37 | 5.30 | 5.30 |
| 320.41 | 4.56 | 4.56 |
| 316.40 | 5.18 | 5.18 |
| 314.38 | 4.98 | 4.98 |
| 316.40 | 4.84 | 4.84 |
| 207.19 | 1.62 | 1.62 |
| 209.20 | 1.42 | 1.42 |
| 242.25 | 3.15 | 3.15 |
| 300.36 | 4.68 | 4.68 |
| 274.32 | 4.16 | 4.16 |