Basic Information
ID: ALA3707920
Type: Binding
Description: Fluorescence Quenching Assay: CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS (site 1) and FRS (site 5) regions, whereas predicted docking sites are labeled sites 2-4 (Table 6). One compound, 76, that targets the DRS is being marketed by Calbiochem/EMD Biosciences (Cat#328006) as an ERK inhibitor. Successful inhibitor identification to date has been based on a combination of fluorescence quenching (FQ) of ERK2 wild type and docking site mutants in the presence of test compound.
Organism: Mus musculus
Activity Charts
Bioactivity
Activity Types for Assay ALA3707920
Kd
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 308.43 | 2.25 | 2.25 |
| 308.38 | 1.58 | 1.58 |
| 442.56 | 3.77 | 3.77 |
| 456.38 | 3.89 | 3.89 |
| 435.96 | 3.55 | 3.55 |