Inverse agonist activity at rat G-protein GSalpha fused GPR6 (unknown origin) expressed in HEK293 cell membranes assessed as effect on [35S]GTPgammaS ...

Basic Information

ID: ALA3720810

Type: Functional

Description: Inverse agonist activity at rat G-protein GSalpha fused GPR6 (unknown origin) expressed in HEK293 cell membranes assessed as effect on [35S]GTPgammaS binding pre-incubated for 5 to 10 mins followed by 60 mins incubation in presence of [35S]GTPgammaS by scintillation proximity assay

Format: BAO_0000219

Organism: Homo sapiens

Cell type: HEK293

Target: G-protein coupled receptor 6(ALA3714130)

Document: ALA3714732

Inverse agonist activity at rat G-protein GSalpha fused GPR6 (unknown origin) expressed in HEK293 cell membranes assessed as effect on [35S]GTPgammaS binding pre-incubated for 5 to 10 mins followed by 60 mins incubation in presence of [35S]GTPgammaS by scintillation proximity assay: 38

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA3720810

IC50

Total(41)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
271.39	0.95	0.95
269.38	2.31	2.31
265.36	0.89	0.89
263.35	2.25	2.25
333.36	1.91	1.91
331.34	3.27	3.27
321.47	2.19	2.19
319.46	3.55	3.55
299.81	1.54	1.54
297.79	2.90	2.90
295.39	0.90	0.90
293.37	2.26	2.26
295.39	0.90	0.90
293.37	2.26	2.26
279.39	1.20	1.20
277.37	2.56	2.56
301.34	1.17	1.17
299.33	2.53	2.53
283.35	1.03	1.03
281.34	2.39	2.39
283.35	1.03	1.03
281.34	2.39	2.39
283.35	1.03	1.03
281.34	2.39	2.39
315.42	2.04	2.04
313.41	3.40	3.40
315.42	2.04	2.04
313.41	3.40	3.40
321.45	2.11	2.11
319.44	3.46	3.46
255.32	0.48	0.48
253.31	1.84	1.84
282.35	1.85	1.85
256.31	-0.12	-0.12
254.30	1.24	1.24
433.87	2.75	2.75
431.85	4.11	4.11
344.42	3.21	3.21
312.45	1.01	1.01
266.35	0.29	0.29
264.33	1.64	1.64