Agonist activity at human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as calcium mobilization by fluo-4-AM dye based FLIPR as...

Basic Information

ID: ALA3720907

Type: Functional

Description: Agonist activity at human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as calcium mobilization by fluo-4-AM dye based FLIPR assay

Format: BAO_0000219

Organism: Homo sapiens

Cell type: HEK-293T

Target: T1R1/T1R3(ALA3832641)

Document: ALA3714709

Agonist activity at human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as calcium mobilization by fluo-4-AM dye based FLIPR assay: 38

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA3720907

EC50

Total(140)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
339.44	3.85	3.85
284.33	4.02	4.02
291.44	4.34	4.34
265.42	4.11	4.11
266.34	3.01	3.01
371.44	1.77	1.77
249.35	3.17	3.17
293.32	1.88	1.88
275.35	3.61	3.61
310.18	4.64	4.64
293.22	3.76	3.76
275.39	3.51	3.51
305.37	2.41	2.41
305.37	2.56	2.56
285.41	3.90	3.90
275.39	3.79	3.79
251.40	3.85	3.85
247.34	3.01	3.01
305.42	3.28	3.28
211.35	3.43	3.43
281.38	2.47	2.47
275.35	2.40	2.40
209.33	2.89	2.89
247.34	3.01	3.01
263.34	2.25	2.25
251.40	3.85	3.85
353.45	2.58	2.58
341.41	1.84	1.84
268.79	4.43	4.43
323.22	5.27	5.27
266.77	4.04	4.04
252.33	3.92	3.92
280.80	4.43	4.43
283.38	3.57	3.57
300.79	4.54	4.54
292.38	3.40	3.40
262.40	4.34	4.34
276.38	3.79	3.79
262.35	3.40	3.40
297.35	3.21	3.21
299.37	3.12	3.12
307.39	2.63	2.63
313.40	3.89	3.89
265.35	2.55	2.55
285.77	2.49	2.49
263.34	2.31	2.31
303.79	4.15	4.15
265.35	3.10	3.10
281.36	3.51	3.51
339.82	3.20	3.20
347.41	4.30	4.30
277.37	4.14	4.14
301.77	3.77	3.77
332.36	1.27	1.27
297.40	3.75	3.75
281.78	3.66	3.66
245.37	4.03	4.03
249.35	3.39	3.39
255.75	3.27	3.27
265.42	4.03	4.03
307.39	2.79	2.79
233.35	3.69	3.69
265.35	3.10	3.10
277.36	2.62	2.62
311.40	2.03	2.03
297.35	3.21	3.21
279.45	4.13	4.13
319.79	3.85	3.85
249.35	3.39	3.39
291.39	2.96	2.96
263.38	3.56	3.56
309.43	3.12	3.12
263.38	3.70	3.70
263.34	2.23	2.23
293.36	2.32	2.32
249.35	3.31	3.31
295.45	3.51	3.51
337.38	2.82	2.82
299.75	2.42	2.42
263.38	3.78	3.78
263.34	2.31	2.31
287.32	4.40	4.40
247.38	3.95	3.95
277.41	3.95	3.95
293.36	2.32	2.32
267.34	3.53	3.53
293.32	1.73	1.73
291.35	1.94	1.94
295.34	3.22	3.22
297.35	3.17	3.17
279.29	1.49	1.49
263.34	3.57	3.57
321.37	2.51	2.51
261.36	3.32	3.32
249.31	2.72	2.72
265.42	4.03	4.03
313.78	2.81	2.81
233.35	3.61	3.61
275.35	2.65	2.65
288.19	3.74	3.74
237.34	3.60	3.60
235.33	3.14	3.14
287.40	4.69	4.69
235.33	3.20	3.20
288.35	2.49	2.49
258.37	3.87	3.87
288.35	2.49	2.49
300.36	2.55	2.55
239.38	3.76	3.76
271.38	3.86	3.86
299.37	3.16	3.16
291.39	3.89	3.89
293.32	1.73	1.73
293.32	1.88	1.88
289.38	3.85	3.85
303.40	4.39	4.39
291.35	2.99	2.99
231.29	3.35	3.35
276.41	3.99	3.99
288.39	4.08	4.08
288.39	4.08	4.08
304.35	2.45	2.45
274.36	3.69	3.69
274.36	3.83	3.83
304.35	2.45	2.45
260.34	3.53	3.53
305.40	3.22	3.22
289.33	2.75	2.75
319.36	2.76	2.76
305.37	3.23	3.23
273.38	4.30	4.30
289.33	2.75	2.75
289.38	4.14	4.14
281.74	3.24	3.24
289.38	4.00	4.00
261.32	3.36	3.36
337.40	2.47	2.47
345.40	3.29	3.29
340.21	4.65	4.65
354.19	4.04	4.04