Basic Information
ID: ALA3721050
Type: Functional
Description: Antagonist activity against human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2-induced intracellular calcium mobilization incubated for 30 mins before agonist addition by FLIPR assay
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA3721050
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 485.53 | 5.26 | 5.26 |
| 551.55 | 7.49 | 7.49 |
| 485.53 | 5.26 | 5.26 |
| 539.64 | 7.68 | 7.68 |
| 502.55 | 6.07 | 6.07 |
| 473.51 | 6.06 | 6.06 |
| 502.53 | 6.00 | 6.00 |
| 527.60 | 6.78 | 6.78 |
| 489.58 | 6.53 | 6.53 |
| 487.54 | 5.20 | 5.20 |
| 504.59 | 6.23 | 6.23 |
| 539.64 | 7.68 | 7.68 |
| 509.55 | 5.73 | 5.73 |
| 502.53 | 6.00 | 6.00 |
| 528.59 | 6.18 | 6.18 |
| 484.54 | 5.86 | 5.86 |
| 551.55 | 7.49 | 7.49 |
| 519.53 | 6.75 | 6.75 |
| 527.56 | 6.20 | 6.20 |
| 545.58 | 5.27 | 5.27 |
| 541.61 | 6.47 | 6.47 |
| 523.57 | 6.11 | 6.11 |
| 524.56 | 5.51 | 5.51 |
| 514.56 | 5.87 | 5.87 |
| 498.56 | 6.17 | 6.17 |
| 498.56 | 6.17 | 6.17 |
| 516.55 | 6.31 | 6.31 |
| 520.52 | 6.14 | 6.14 |
| 514.56 | 5.87 | 5.87 |
| 509.55 | 5.73 | 5.73 |
| 518.98 | 6.52 | 6.52 |
| 543.61 | 6.05 | 6.05 |
| 516.55 | 6.31 | 6.31 |
| 516.55 | 6.31 | 6.31 |
| 514.56 | 5.87 | 5.87 |
| 516.54 | 5.16 | 5.16 |
| 510.54 | 5.13 | 5.13 |
| 552.53 | 6.88 | 6.88 |
| 502.53 | 6.00 | 6.00 |
| 502.53 | 6.00 | 6.00 |
| 509.55 | 5.73 | 5.73 |
| 515.55 | 5.27 | 5.27 |
| 490.57 | 5.92 | 5.92 |
| 527.61 | 5.93 | 5.93 |
| 536.97 | 6.65 | 6.65 |
| 533.01 | 6.82 | 6.82 |
| 515.55 | 5.27 | 5.27 |
| 553.43 | 7.17 | 7.17 |
| 502.53 | 6.00 | 6.00 |
| 518.98 | 6.52 | 6.52 |
| 597.65 | 5.33 | 5.33 |
| 545.58 | 5.24 | 5.24 |
| 569.64 | 5.70 | 5.70 |
| 584.65 | 6.82 | 6.82 |
| 648.74 | 8.15 | 8.15 |
| 532.55 | 6.01 | 6.01 |
| 519.53 | 6.36 | 6.36 |
| 474.50 | 5.46 | 5.46 |
| 549.01 | 6.52 | 6.52 |
| 536.54 | 7.10 | 7.10 |
| 536.54 | 7.10 | 7.10 |
| 538.51 | 6.28 | 6.28 |
| 545.58 | 5.27 | 5.27 |
| 484.54 | 5.86 | 5.86 |
| 514.56 | 5.87 | 5.87 |
| 519.97 | 5.91 | 5.91 |
| 516.54 | 4.66 | 4.66 |
| 519.97 | 5.91 | 5.91 |
| 516.54 | 4.66 | 4.66 |
| 514.56 | 5.87 | 5.87 |
| 470.58 | 6.57 | 6.57 |
| 444.47 | 5.45 | 5.45 |
| 493.52 | 5.50 | 5.50 |
| 533.54 | 5.40 | 5.40 |
| 528.55 | 5.56 | 5.56 |
| 599.67 | 5.58 | 5.58 |
| 612.71 | 7.47 | 7.47 |
| 528.59 | 5.92 | 5.92 |
| 583.67 | 7.37 | 7.37 |
| 584.65 | 6.77 | 6.77 |
| 499.55 | 6.17 | 6.17 |
| 500.54 | 5.57 | 5.57 |
| 491.57 | 5.69 | 5.69 |
| 489.55 | 5.60 | 5.60 |
| 487.58 | 6.76 | 6.76 |
| 489.60 | 6.85 | 6.85 |
| 555.62 | 5.56 | 5.56 |
| 504.50 | 4.79 | 4.79 |
| 556.60 | 4.96 | 4.96 |
| 510.54 | 5.13 | 5.13 |
| 515.55 | 5.27 | 5.27 |
| 485.53 | 5.26 | 5.26 |
| 506.57 | 5.02 | 5.02 |
| 449.49 | 4.47 | 4.47 |
| 543.56 | 5.10 | 5.10 |
| 525.59 | 5.67 | 5.67 |
| 534.62 | 5.72 | 5.72 |
| 519.97 | 5.91 | 5.91 |
| 519.97 | 5.91 | 5.91 |
| 508.56 | 4.19 | 4.19 |
| 524.57 | 5.22 | 5.22 |
| 522.58 | 4.85 | 4.85 |
| 538.60 | 5.87 | 5.87 |
| 510.55 | 5.17 | 5.17 |
| 526.57 | 6.19 | 6.19 |