Basic Information
ID: ALA3721107
Type: Binding
Description: Inhibition of N-terminally GST-tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminal His-tagged MKK4 K131M substrate incubated for 60 mins by TR-FRET assay
Format: BAO_0000357
Organism: Homo sapiens
Target: Mitogen-activated protein kinase kinase kinase 12(ALA1908389)
Document: ALA3714745
Inhibition of N-terminally GST-tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminal His-tagged MKK4 K131M substrate incubated for 60 mins by TR-FRET assay: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA3721107
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 431.46 | 4.07 | 4.07 |
| 379.47 | 2.03 | 2.03 |
| 415.41 | 4.04 | 4.04 |
| 381.48 | 2.60 | 2.60 |
| 403.91 | 2.72 | 2.72 |
| 383.47 | 3.72 | 3.72 |
| 409.46 | 3.71 | 3.71 |
| 390.49 | 3.46 | 3.46 |
| 375.90 | 3.34 | 3.34 |
| 366.47 | 2.98 | 2.98 |
| 409.53 | 3.33 | 3.33 |
| 435.49 | 4.24 | 4.24 |
| 355.49 | 2.99 | 2.99 |
| 385.51 | 3.09 | 3.09 |
| 399.54 | 3.47 | 3.47 |
| 447.53 | 3.86 | 3.86 |
| 461.56 | 4.25 | 4.25 |
| 473.57 | 4.25 | 4.25 |
| 397.52 | 3.23 | 3.23 |
| 371.49 | 2.70 | 2.70 |
| 425.58 | 4.01 | 4.01 |
| 437.92 | 4.12 | 4.12 |
| 366.47 | 2.56 | 2.56 |
| 392.51 | 3.09 | 3.09 |
| 383.50 | 2.91 | 2.91 |
| 395.55 | 3.81 | 3.81 |
| 381.52 | 3.46 | 3.46 |
| 437.47 | 3.09 | 3.09 |
| 381.52 | 3.56 | 3.56 |
| 407.46 | 3.29 | 3.29 |
| 433.50 | 3.47 | 3.47 |
| 431.51 | 5.76 | 5.76 |
| 407.48 | 4.86 | 4.86 |
| 439.48 | 3.46 | 3.46 |
| 352.36 | 3.49 | 3.49 |
| 344.85 | 3.66 | 3.66 |
| 326.37 | 3.51 | 3.51 |
| 391.32 | 3.04 | 3.04 |
| 429.47 | 2.73 | 2.73 |
| 431.41 | 3.92 | 3.92 |
| 413.83 | 2.96 | 2.96 |
| 441.89 | 3.42 | 3.42 |
| 402.42 | 3.02 | 3.02 |
| 405.43 | 3.19 | 3.19 |
| 393.41 | 3.32 | 3.32 |
| 415.85 | 3.03 | 3.03 |
| 409.46 | 3.42 | 3.42 |
| 375.90 | 3.05 | 3.05 |
| 407.47 | 3.00 | 3.00 |
| 389.93 | 3.13 | 3.13 |
| 423.90 | 3.13 | 3.13 |
| 421.47 | 3.25 | 3.25 |
| 387.92 | 2.88 | 2.88 |
| 435.49 | 3.64 | 3.64 |
| 425.46 | 3.30 | 3.30 |
| 449.40 | 3.40 | 3.40 |
| 404.44 | 3.69 | 3.69 |
| 423.48 | 3.54 | 3.54 |
| 423.48 | 3.81 | 3.81 |
| 437.47 | 4.32 | 4.32 |
| 418.47 | 4.07 | 4.07 |
| 388.48 | 2.92 | 2.92 |
| 407.44 | 3.17 | 3.17 |
| 433.48 | 3.71 | 3.71 |
| 399.93 | 3.34 | 3.34 |
| 431.49 | 3.29 | 3.29 |
| 390.49 | 2.56 | 2.56 |
| 405.55 | 3.56 | 3.56 |
| 373.89 | 2.81 | 2.81 |
| 405.45 | 2.75 | 2.75 |
| 379.51 | 3.03 | 3.03 |
| 393.54 | 3.27 | 3.27 |
| 364.45 | 2.02 | 2.02 |
| 369.47 | 2.16 | 2.16 |
| 397.52 | 2.94 | 2.94 |
| 385.90 | 2.95 | 2.95 |
| 419.45 | 3.32 | 3.32 |
| 409.53 | 3.08 | 3.08 |
| 413.83 | 2.79 | 2.79 |
| 417.46 | 2.90 | 2.90 |
| 419.45 | 3.00 | 3.00 |
| 391.52 | 3.17 | 3.17 |
| 385.90 | 2.63 | 2.63 |
| 443.57 | 2.09 | 2.09 |
| 423.56 | 3.47 | 3.47 |
| 395.51 | 2.70 | 2.70 |
| 389.45 | 3.09 | 3.09 |
| 381.48 | 2.30 | 2.30 |
| 433.48 | 3.39 | 3.39 |
| 391.52 | 2.86 | 2.86 |
| 405.55 | 3.25 | 3.25 |
| 435.45 | 3.19 | 3.19 |
| 431.49 | 2.97 | 2.97 |
| 423.44 | 3.05 | 3.05 |
| 449.48 | 3.59 | 3.59 |
| 421.47 | 3.35 | 3.35 |
| 405.42 | 2.93 | 2.93 |
| 401.46 | 2.92 | 2.92 |
| 387.43 | 2.84 | 2.84 |
| 415.49 | 3.62 | 3.62 |