Assay Report Card

Basic Information

ID: ALA3721139

Type: Functional

Description: Antagonist activity against human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2-induced intracellular calcium mobilization incubated for 30 mins by FLIPR assay

Organism: Homo sapiens

Cell type: HEK293

Activity Charts

Bioactivity

Activity Types for Assay ALA3721139

EC50

Total(310)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
527.63	4.87	4.87
598.50	7.07	7.07
597.72	6.37	6.37
601.71	6.28	6.28
603.75	5.17	5.17
575.69	4.40	4.40
637.77	5.83	5.83
629.66	5.29	5.29
532.59	6.55	6.55
481.52	4.91	4.91
481.52	4.91	4.91
514.59	4.25	4.25
516.58	5.23	5.23
528.61	4.91	4.91
542.64	5.03	5.03
544.63	6.01	6.01
500.56	3.86	3.86
528.61	4.56	4.56
570.65	4.76	4.76
554.65	5.66	5.66
526.60	4.59	4.59
613.72	5.48	5.48
617.71	5.38	5.38
582.58	5.27	5.27
550.58	6.63	6.63
584.57	6.25	6.25
512.61	5.41	5.41
514.60	6.39	6.39
548.59	5.65	5.65
588.59	6.05	6.05
540.55	5.42	5.42
542.54	6.39	6.39
500.60	5.26	5.26
502.59	6.24	6.24
540.67	6.04	6.04
526.52	5.03	5.03
524.62	5.26	5.26
623.03	6.71	6.71
594.64	6.59	6.59
518.59	5.48	5.48
594.72	6.78	6.78
612.73	5.98	5.98
556.62	4.72	4.72
609.73	5.26	5.26
534.02	4.75	4.75
562.63	5.99	5.99
520.59	5.42	5.42
547.62	5.33	5.33
523.57	5.77	5.77
533.59	5.02	5.02
505.58	5.63	5.63
576.66	6.30	6.30
534.62	5.72	5.72
523.57	5.77	5.77
521.58	5.33	5.33
526.00	5.97	5.97
568.66	5.33	5.33
504.59	6.48	6.48
525.01	6.58	6.58
567.57	5.11	5.11
443.51	4.15	4.15
527.58	3.91	3.91
529.60	3.59	3.59
543.63	4.24	4.24
557.65	4.32	4.32
525.61	4.62	4.62
539.64	4.93	4.93
513.60	4.40	4.40
512.61	5.46	5.46
483.51	3.62	3.62
497.53	3.93	3.93
509.54	4.16	4.16
598.71	5.31	5.31
576.68	3.34	3.34
663.76	4.64	4.64
604.74	4.12	4.12
555.64	4.60	4.60
511.59	4.09	4.09
527.63	4.66	4.66
496.57	4.61	4.61
589.70	6.19	6.19
533.58	5.49	5.49
492.54	4.71	4.71
495.54	5.22	5.22
414.47	4.26	4.26
493.36	5.02	5.02
561.65	5.63	5.63
548.60	5.71	5.71
548.65	6.15	6.15
605.70	5.64	5.64
547.62	5.28	5.28
589.70	6.45	6.45
603.73	6.75	6.75
551.63	6.58	6.58
604.71	7.19	7.19
548.60	5.93	5.93
629.64	6.52	6.52
600.68	5.83	5.83
561.65	5.59	5.59
471.56	4.32	4.32
527.63	4.87	4.87
456.55	5.38	5.38
515.64	4.81	4.81
547.64	3.49	3.49
531.64	3.83	3.83
513.60	4.48	4.48
534.58	5.65	5.65
510.52	5.75	5.75
514.65	5.87	5.87
482.59	5.60	5.60
515.58	5.80	5.80
548.60	5.85	5.85
506.57	5.63	5.63
515.58	5.80	5.80
561.65	5.63	5.63
575.67	5.93	5.93
509.54	5.46	5.46
609.13	7.01	7.01
609.13	7.01	7.01
608.70	4.62	4.62
653.58	7.12	7.12
592.67	6.49	6.49
588.71	6.66	6.66
604.71	6.36	6.36
604.71	6.36	6.36
632.72	6.14	6.14
645.76	6.06	6.06
574.68	6.35	6.35
595.10	6.62	6.62
574.68	6.27	6.27
595.10	6.62	6.62
578.65	6.10	6.10
512.61	5.32	5.32
546.63	6.17	6.17
544.61	6.08	6.08
617.78	5.31	5.31
633.77	4.98	4.98
550.06	4.22	4.22
670.77	4.90	4.90
598.71	3.94	3.94
532.65	6.58	6.58
567.09	7.24	7.24
545.65	6.12	6.12
518.58	5.11	5.11
478.53	6.05	6.05
602.67	6.43	6.43
603.58	6.35	6.35
591.69	6.92	6.92
575.65	6.29	6.29
574.62	5.65	5.65
549.61	5.76	5.76
549.61	5.72	5.72
494.99	6.57	6.57
529.43	7.22	7.22
509.01	6.88	6.88
519.00	4.90	4.90
460.54	5.92	5.92
506.58	6.95	6.95
515.59	5.12	5.12
577.66	6.65	6.65
494.55	7.08	7.08
530.60	5.28	5.28
532.59	6.25	6.25
558.66	6.05	6.05
560.65	7.03	7.03
544.63	5.59	5.59
495.54	6.41	6.41
468.54	6.16	6.16
492.63	6.11	6.11
471.34	5.26	5.26
426.89	5.15	5.15
490.59	4.25	4.25
536.54	7.18	7.18
502.98	6.82	6.82
552.53	7.06	7.06
469.53	5.56	5.56
494.55	5.47	5.47
476.56	5.39	5.39
498.56	6.17	6.17
477.55	4.33	4.33
505.60	5.11	5.11
493.61	5.05	5.05
491.57	4.72	4.72
512.55	5.89	5.89
545.54	5.35	5.35
526.57	6.09	6.09
484.54	5.87	5.87
505.60	4.89	4.89
539.62	5.86	5.86
493.55	6.03	6.03
553.64	6.17	6.17
540.60	6.23	6.23
501.54	6.00	6.00
487.52	5.70	5.70
554.63	6.53	6.53
512.59	5.96	5.96
483.55	5.87	5.87
503.97	6.21	6.21
546.63	5.57	5.57
511.55	5.73	5.73
554.65	3.58	3.58
641.74	4.88	4.88
510.57	6.79	6.79
587.10	7.24	7.24
573.07	6.85	6.85
566.68	6.90	6.90
520.62	3.61	3.61
520.62	4.24	4.24
498.57	5.50	5.50
523.62	4.59	4.59
554.64	4.61	4.61
526.62	6.30	6.30
465.54	3.92	3.92
474.55	4.84	4.84
465.54	4.55	4.55
518.64	5.03	5.03
477.55	4.07	4.07
532.63	4.92	4.92
449.54	5.32	5.32
491.57	5.09	5.09
447.52	4.71	4.71
489.60	5.73	5.73
508.56	6.11	6.11
522.59	6.72	6.72
552.66	5.82	5.82
553.65	5.22	5.22
512.60	6.25	6.25
519.53	6.52	6.52
515.57	6.69	6.69
497.58	6.55	6.55
587.11	6.48	6.48
540.65	6.17	6.17
567.68	5.21	5.21
503.63	6.12	6.12
493.56	5.43	5.43
463.56	5.34	5.34
540.63	6.85	6.85
560.68	4.80	4.80
475.57	5.48	5.48
475.57	5.48	5.48
504.62	4.64	4.64
491.57	4.72	4.72
501.61	5.88	5.88
435.51	4.56	4.56
516.56	6.08	6.08
513.58	6.25	6.25
588.09	5.87	5.87
567.68	5.53	5.53
560.68	4.80	4.80
603.73	6.79	6.79
600.68	5.91	5.91
573.66	5.77	5.77
589.66	4.74	4.74
623.66	6.40	6.40
614.71	6.30	6.30
577.64	4.65	4.65
603.68	5.39	5.39
589.66	5.05	5.05
587.68	6.18	6.18
603.73	6.79	6.79
603.68	5.39	5.39
601.71	6.55	6.55
591.67	4.99	4.99
587.68	6.16	6.16
615.74	6.80	6.80
615.74	6.94	6.94
575.67	6.06	6.06
615.62	6.22	6.22
561.65	5.67	5.67
604.71	5.22	5.22
575.67	6.02	6.02
603.73	6.80	6.80
589.70	6.40	6.40
600.68	5.91	5.91
615.74	6.80	6.80
643.79	7.57	7.57
601.71	6.41	6.41
573.66	5.82	5.82
613.72	6.69	6.69
615.74	6.94	6.94
428.50	4.57	4.57
482.47	5.28	5.28
490.57	5.92	5.92
490.57	5.92	5.92
499.57	4.09	4.09
502.57	4.42	4.42
491.55	5.32	5.32
491.55	5.32	5.32
474.50	4.38	4.38
474.50	4.38	4.38
558.56	6.94	6.94
504.59	6.23	6.23
504.59	6.23	6.23
498.59	5.15	5.15
508.56	6.06	6.06
525.01	6.58	6.58
558.56	6.94	6.94
520.59	5.93	5.93
520.59	5.93	5.93
496.61	6.30	6.30
497.60	5.25	5.25
512.62	4.01	4.01
442.52	4.82	4.82
526.55	6.20	6.20
508.56	6.06	6.06
508.56	6.06	6.06
525.01	6.58	6.58
491.55	5.32	5.32
574.56	6.82	6.82
491.55	5.32	5.32