Basic Information
ID: ALA3734174
Type: Functional
Description: Antagonist activity against human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2-induced intracellular calcium mobilization incubated for 30 mins before agonist addition by FLIPR assay
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA3734174
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 287.37 | 3.93 | 3.93 |
| 304.43 | 3.79 | 3.79 |
| 288.36 | 3.08 | 3.08 |
| 334.45 | 3.80 | 3.80 |
| 301.33 | 3.22 | 3.22 |
| 331.35 | 3.23 | 3.23 |
| 317.40 | 3.93 | 3.93 |
| 313.38 | 4.17 | 4.17 |
| 317.40 | 3.93 | 3.93 |
| 317.40 | 3.93 | 3.93 |
| 317.40 | 3.93 | 3.93 |
| 301.40 | 4.23 | 4.23 |
| 301.40 | 4.23 | 4.23 |
| 321.81 | 4.58 | 4.58 |
| 331.42 | 4.24 | 4.24 |
| 361.45 | 4.25 | 4.25 |
| 302.38 | 3.47 | 3.47 |
| 315.35 | 3.61 | 3.61 |
| 345.38 | 3.54 | 3.54 |
| 299.36 | 3.78 | 3.78 |
| 306.30 | 3.44 | 3.44 |
| 300.34 | 3.17 | 3.17 |
| 304.76 | 3.81 | 3.81 |
| 255.30 | 3.51 | 3.51 |
| 284.34 | 3.47 | 3.47 |
| 300.34 | 3.17 | 3.17 |
| 304.76 | 3.81 | 3.81 |
| 298.37 | 3.78 | 3.78 |
| 269.33 | 3.77 | 3.77 |
| 288.31 | 3.30 | 3.30 |
| 328.40 | 3.95 | 3.95 |
| 324.37 | 3.67 | 3.67 |
| 327.41 | 4.56 | 4.56 |
| 326.43 | 4.46 | 4.46 |
| 298.37 | 3.78 | 3.78 |
| 285.33 | 3.47 | 3.47 |
| 399.47 | 4.49 | 4.49 |
| 299.36 | 3.78 | 3.78 |
| 371.42 | 3.71 | 3.71 |
| 281.34 | 4.08 | 4.08 |
| 341.44 | 4.95 | 4.95 |
| 427.53 | 5.27 | 5.27 |
| 352.42 | 4.45 | 4.45 |
| 376.44 | 4.74 | 4.74 |
| 320.17 | 3.97 | 3.97 |
| 270.32 | 3.25 | 3.25 |
| 371.37 | 4.82 | 4.82 |
| 301.33 | 3.22 | 3.22 |
| 345.38 | 3.54 | 3.54 |
| 331.35 | 3.23 | 3.23 |
| 340.41 | 3.95 | 3.95 |
| 340.41 | 4.09 | 4.09 |
| 382.49 | 5.12 | 5.12 |
| 356.45 | 4.59 | 4.59 |
| 404.50 | 5.17 | 5.17 |
| 342.42 | 4.34 | 4.34 |
| 368.46 | 4.87 | 4.87 |
| 410.89 | 5.39 | 5.39 |
| 410.89 | 5.39 | 5.39 |
| 410.89 | 5.39 | 5.39 |
| 406.47 | 4.75 | 4.75 |
| 342.42 | 4.20 | 4.20 |
| 377.43 | 4.14 | 4.14 |
| 328.40 | 3.95 | 3.95 |
| 285.33 | 3.52 | 3.52 |
| 285.33 | 3.52 | 3.52 |
| 305.75 | 3.87 | 3.87 |
| 299.36 | 3.78 | 3.78 |
| 301.33 | 3.22 | 3.22 |
| 305.75 | 3.87 | 3.87 |
| 285.33 | 3.52 | 3.52 |
| 289.29 | 3.35 | 3.35 |
| 289.29 | 3.35 | 3.35 |
| 355.30 | 4.11 | 4.11 |
| 316.30 | 3.12 | 3.12 |
| 316.30 | 3.12 | 3.12 |
| 313.38 | 4.34 | 4.34 |
| 299.36 | 3.83 | 3.83 |
| 331.35 | 3.23 | 3.23 |
| 377.43 | 4.79 | 4.79 |
| 347.42 | 3.94 | 3.94 |
| 331.42 | 4.24 | 4.24 |
| 315.42 | 4.54 | 4.54 |
| 287.30 | 2.92 | 2.92 |
| 305.75 | 3.87 | 3.87 |
| 288.36 | 3.32 | 3.32 |
| 272.29 | 2.61 | 2.61 |
| 270.32 | 3.22 | 3.22 |
| 302.38 | 3.63 | 3.63 |
| 401.52 | 3.80 | 3.80 |
| 394.48 | 4.90 | 4.90 |
| 318.38 | 3.33 | 3.33 |
| 395.47 | 4.29 | 4.29 |
| 350.40 | 3.67 | 3.67 |
| 424.51 | 4.91 | 4.91 |
| 303.37 | 2.90 | 2.90 |
| 408.44 | 4.20 | 4.20 |
| 320.32 | 4.02 | 4.02 |
| 351.29 | 3.62 | 3.62 |
| 321.31 | 3.29 | 3.29 |
| 322.80 | 3.97 | 3.97 |
| 306.35 | 3.46 | 3.46 |
| 286.32 | 2.92 | 2.92 |
| 302.38 | 3.63 | 3.63 |
| 286.32 | 2.92 | 2.92 |
| 306.73 | 3.26 | 3.26 |
| 358.49 | 5.01 | 5.01 |
| 344.47 | 4.62 | 4.62 |
| 316.41 | 3.94 | 3.94 |
| 328.40 | 3.91 | 3.91 |
| 290.28 | 2.75 | 2.75 |
| 300.34 | 3.22 | 3.22 |
| 324.34 | 3.60 | 3.60 |
| 308.27 | 2.89 | 2.89 |
| 372.35 | 4.22 | 4.22 |
| 356.29 | 3.51 | 3.51 |
| 318.38 | 3.33 | 3.33 |
| 302.32 | 2.62 | 2.62 |
| 306.35 | 3.46 | 3.46 |
| 290.28 | 2.75 | 2.75 |
| 395.47 | 4.29 | 4.29 |
| 395.47 | 4.29 | 4.29 |
| 304.36 | 3.03 | 3.03 |
| 394.48 | 4.90 | 4.90 |
| 318.38 | 3.33 | 3.33 |
| 419.49 | 4.77 | 4.77 |
| 428.93 | 5.55 | 5.55 |
| 430.46 | 5.18 | 5.18 |
| 462.48 | 5.92 | 5.92 |
| 395.47 | 4.29 | 4.29 |
| 462.48 | 5.92 | 5.92 |
| 419.49 | 4.77 | 4.77 |
| 428.93 | 5.55 | 5.55 |
| 332.41 | 3.72 | 3.72 |
| 346.44 | 4.11 | 4.11 |
| 332.41 | 3.72 | 3.72 |
| 346.44 | 4.11 | 4.11 |
| 348.41 | 3.30 | 3.30 |
| 348.41 | 3.30 | 3.30 |
| 302.32 | 2.62 | 2.62 |
| 446.41 | 5.21 | 5.21 |
| 395.47 | 4.29 | 4.29 |
| 395.47 | 4.29 | 4.29 |
| 417.52 | 3.03 | 3.03 |
| 428.93 | 5.55 | 5.55 |
| 424.51 | 4.91 | 4.91 |
| 430.46 | 5.18 | 5.18 |
| 424.51 | 4.91 | 4.91 |
| 500.61 | 6.48 | 6.48 |
| 358.45 | 4.11 | 4.11 |
| 358.45 | 4.11 | 4.11 |
| 303.37 | 2.90 | 2.90 |
| 348.41 | 3.34 | 3.34 |
| 306.30 | 3.71 | 3.71 |
| 334.35 | 4.33 | 4.33 |
| 388.42 | 4.69 | 4.69 |
| 388.42 | 4.69 | 4.69 |
| 322.42 | 3.93 | 3.93 |
| 355.22 | 3.97 | 3.97 |
| 306.35 | 3.22 | 3.22 |
| 322.37 | 4.18 | 4.18 |
| 304.38 | 4.10 | 4.10 |
| 338.87 | 4.44 | 4.44 |
| 338.87 | 4.44 | 4.44 |
| 364.48 | 3.81 | 3.81 |
| 318.45 | 4.10 | 4.10 |
| 322.42 | 3.93 | 3.93 |
| 352.90 | 4.75 | 4.75 |
| 355.22 | 3.97 | 3.97 |
| 306.35 | 3.22 | 3.22 |
| 372.35 | 3.97 | 3.97 |
| 322.80 | 3.73 | 3.73 |
| 302.38 | 3.38 | 3.38 |
| 356.81 | 4.83 | 4.83 |
| 336.39 | 4.49 | 4.49 |
| 384.64 | 4.63 | 4.63 |
| 335.77 | 3.87 | 3.87 |
| 351.84 | 4.59 | 4.59 |
| 407.45 | 4.80 | 4.80 |
| 317.33 | 2.93 | 2.93 |
| 513.58 | 6.38 | 6.38 |
| 345.38 | 3.62 | 3.62 |
| 305.31 | 4.32 | 4.32 |
| 341.29 | 4.56 | 4.56 |
| 325.73 | 4.49 | 4.49 |
| 377.43 | 4.79 | 4.79 |
| 287.30 | 2.92 | 2.92 |
| 347.37 | 4.25 | 4.25 |
| 356.21 | 5.54 | 5.54 |
| 356.21 | 5.54 | 5.54 |
| 303.37 | 3.63 | 3.63 |
| 347.42 | 3.91 | 3.91 |
| 394.48 | 4.90 | 4.90 |
| 331.35 | 3.20 | 3.20 |
| 410.25 | 3.96 | 3.96 |
| 370.38 | 4.65 | 4.65 |
| 331.38 | 3.62 | 3.62 |
| 420.52 | 4.86 | 4.86 |
| 322.80 | 3.97 | 3.97 |
| 355.60 | 4.01 | 4.01 |
| 306.73 | 3.26 | 3.26 |
| 407.45 | 4.52 | 4.52 |
| 430.23 | 4.79 | 4.79 |
| 486.35 | 5.56 | 5.56 |
| 423.52 | 5.51 | 5.51 |
| 347.42 | 3.94 | 3.94 |
| 393.49 | 5.50 | 5.50 |
| 323.30 | 4.45 | 4.45 |
| 319.34 | 4.62 | 4.62 |
| 319.34 | 4.62 | 4.62 |
| 319.34 | 4.62 | 4.62 |
| 339.75 | 4.97 | 4.97 |
| 339.75 | 4.97 | 4.97 |
| 374.20 | 5.62 | 5.62 |
| 369.78 | 4.98 | 4.98 |
| 389.31 | 5.21 | 5.21 |
| 411.43 | 5.89 | 5.89 |
| 365.36 | 4.33 | 4.33 |
| 343.72 | 4.63 | 4.63 |
| 339.75 | 4.80 | 4.80 |
| 305.31 | 4.37 | 4.37 |
| 393.44 | 5.81 | 5.81 |
| 287.32 | 4.23 | 4.23 |
| 342.41 | 3.83 | 3.83 |
| 411.48 | 5.64 | 5.64 |
| 411.43 | 5.89 | 5.89 |
| 393.44 | 5.81 | 5.81 |
| 394.25 | 3.99 | 3.99 |
| 499.62 | 7.08 | 7.08 |
| 532.42 | 7.12 | 7.12 |
| 483.55 | 6.37 | 6.37 |
| 345.38 | 3.24 | 3.24 |
| 305.36 | 4.07 | 4.07 |
| 366.26 | 4.69 | 4.69 |
| 338.16 | 4.11 | 4.11 |
| 350.20 | 3.98 | 3.98 |
| 396.29 | 4.70 | 4.70 |
| 305.36 | 4.07 | 4.07 |
| 289.29 | 3.35 | 3.35 |
| 338.16 | 4.11 | 4.11 |
| 441.46 | 5.90 | 5.90 |
| 395.42 | 4.93 | 4.93 |
| 394.25 | 4.37 | 4.37 |
| 361.45 | 3.95 | 3.95 |
| 335.84 | 4.89 | 4.89 |
| 351.79 | 4.90 | 4.90 |
| 351.79 | 4.90 | 4.90 |
| 351.79 | 4.90 | 4.90 |
| 335.34 | 4.32 | 4.32 |
| 414.23 | 5.09 | 5.09 |
| 323.30 | 4.45 | 4.45 |
| 353.78 | 5.28 | 5.28 |
| 429.09 | 4.74 | 4.74 |
| 338.16 | 4.11 | 4.11 |
| 368.64 | 4.93 | 4.93 |
| 380.22 | 3.98 | 3.98 |
| 289.29 | 3.35 | 3.35 |
| 319.77 | 4.17 | 4.17 |
| 402.44 | 4.66 | 4.66 |
| 396.29 | 4.70 | 4.70 |
| 396.29 | 4.70 | 4.70 |
| 396.29 | 4.70 | 4.70 |
| 429.09 | 4.74 | 4.74 |
| 429.09 | 4.74 | 4.74 |
| 356.26 | 5.23 | 5.23 |
| 389.06 | 5.27 | 5.27 |
| 380.22 | 3.98 | 3.98 |
| 380.22 | 3.98 | 3.98 |
| 380.22 | 3.98 | 3.98 |
| 340.19 | 4.52 | 4.52 |
| 317.35 | 4.24 | 4.24 |
| 380.22 | 3.98 | 3.98 |
| 315.42 | 4.54 | 4.54 |
| 348.23 | 4.58 | 4.58 |
| 299.36 | 3.83 | 3.83 |
| 375.48 | 4.72 | 4.72 |
| 408.28 | 4.76 | 4.76 |
| 359.41 | 4.01 | 4.01 |
| 441.51 | 5.65 | 5.65 |
| 474.31 | 5.69 | 5.69 |
| 425.44 | 4.94 | 4.94 |
| 459.45 | 6.04 | 6.04 |
| 354.31 | 3.93 | 3.93 |
| 403.18 | 4.69 | 4.69 |
| 528.59 | 6.08 | 6.08 |
| 528.59 | 6.08 | 6.08 |
| 543.60 | 6.39 | 6.39 |
| 563.64 | 7.53 | 7.53 |
| 549.56 | 6.66 | 6.66 |
| 541.63 | 7.00 | 7.00 |
| 555.66 | 7.50 | 7.50 |
| 549.56 | 6.66 | 6.66 |
| 599.56 | 7.54 | 7.54 |
| 599.56 | 7.54 | 7.54 |
| 589.67 | 8.05 | 8.05 |
| 531.57 | 6.52 | 6.52 |
| 514.56 | 5.77 | 5.77 |
| 549.01 | 6.43 | 6.43 |
| 599.56 | 7.54 | 7.54 |
| 597.57 | 7.28 | 7.28 |
| 566.01 | 7.17 | 7.17 |
| 562.05 | 7.34 | 7.34 |
| 567.55 | 6.80 | 6.80 |
| 581.57 | 7.40 | 7.40 |
| 567.55 | 6.80 | 6.80 |
| 515.55 | 5.17 | 5.17 |
| 567.55 | 6.80 | 6.80 |
| 487.61 | 5.10 | 5.10 |
| 487.61 | 5.10 | 5.10 |
| 620.76 | 5.96 | 5.96 |
| 620.76 | 5.96 | 5.96 |
| 624.75 | 5.86 | 5.86 |
| 630.78 | 5.92 | 5.92 |
| 624.75 | 5.86 | 5.86 |
| 630.78 | 5.92 | 5.92 |
| 431.47 | 3.75 | 3.75 |
| 500.58 | 5.00 | 5.00 |
| 522.56 | 5.04 | 5.04 |
| 500.58 | 5.00 | 5.00 |
| 562.45 | 7.13 | 7.13 |
| 529.64 | 7.09 | 7.09 |
| 531.57 | 6.52 | 6.52 |
| 547.58 | 7.48 | 7.48 |
| 527.60 | 6.77 | 6.77 |
| 548.02 | 7.03 | 7.03 |
| 531.57 | 6.52 | 6.52 |
| 543.60 | 6.39 | 6.39 |
| 527.60 | 6.69 | 6.69 |
| 573.63 | 6.40 | 6.40 |
| 610.46 | 7.28 | 7.28 |
| 527.56 | 6.02 | 6.02 |
| 599.56 | 7.54 | 7.54 |
| 649.73 | 7.97 | 7.97 |
| 581.57 | 7.40 | 7.40 |
| 571.66 | 7.00 | 7.00 |
| 592.47 | 7.14 | 7.14 |
| 608.07 | 7.05 | 7.05 |
| 548.02 | 7.03 | 7.03 |
| 527.60 | 6.69 | 6.69 |
| 617.73 | 8.16 | 8.16 |
| 582.47 | 7.69 | 7.69 |
| 619.70 | 7.96 | 7.96 |
| 622.50 | 7.15 | 7.15 |
| 582.47 | 7.69 | 7.69 |
| 566.01 | 7.17 | 7.17 |
| 566.01 | 7.17 | 7.17 |
| 629.74 | 7.95 | 7.95 |
| 605.67 | 8.17 | 8.17 |
| 649.73 | 7.97 | 7.97 |
| 549.56 | 6.66 | 6.66 |
| 654.14 | 8.61 | 8.61 |
| 582.47 | 7.69 | 7.69 |
| 555.66 | 7.30 | 7.30 |
| 582.47 | 7.69 | 7.69 |
| 639.47 | 6.98 | 6.98 |
| 603.65 | 6.41 | 6.41 |
| 541.63 | 7.00 | 7.00 |
| 541.63 | 7.00 | 7.00 |
| 619.70 | 7.96 | 7.96 |
| 605.67 | 8.17 | 8.17 |
| 599.56 | 7.54 | 7.54 |
| 527.60 | 6.69 | 6.69 |
| 617.73 | 8.28 | 8.28 |
| 573.63 | 6.40 | 6.40 |
| 573.63 | 6.40 | 6.40 |
| 573.63 | 6.40 | 6.40 |
| 639.47 | 6.98 | 6.98 |
| 543.60 | 6.39 | 6.39 |
| 569.68 | 7.68 | 7.68 |
| 597.57 | 7.28 | 7.28 |
| 637.69 | 8.10 | 8.10 |
| 595.60 | 7.71 | 7.71 |
| 632.70 | 7.63 | 7.63 |
| 514.56 | 5.77 | 5.77 |
| 534.62 | 6.14 | 6.14 |
| 581.57 | 7.40 | 7.40 |
| 578.05 | 7.04 | 7.04 |
| 548.02 | 7.03 | 7.03 |
| 543.60 | 6.39 | 6.39 |
| 517.99 | 7.02 | 7.02 |
| 499.62 | 7.08 | 7.08 |
| 529.59 | 7.40 | 7.40 |
| 513.58 | 6.38 | 6.38 |
| 499.55 | 6.08 | 6.08 |
| 511.60 | 6.93 | 6.93 |
| 540.60 | 6.33 | 6.33 |
| 483.55 | 6.37 | 6.37 |
| 517.99 | 7.02 | 7.02 |
| 548.02 | 7.03 | 7.03 |
| 549.56 | 6.97 | 6.97 |
| 508.56 | 6.24 | 6.24 |
| 507.57 | 6.35 | 6.35 |
| 631.61 | 6.60 | 6.60 |
| 647.68 | 7.31 | 7.31 |
| 515.62 | 6.79 | 6.79 |
| 665.62 | 7.70 | 7.70 |
| 543.67 | 7.48 | 7.48 |
| 565.62 | 7.69 | 7.69 |
| 543.63 | 6.62 | 6.62 |
| 527.60 | 6.77 | 6.77 |
| 501.54 | 6.51 | 6.51 |
| 501.54 | 6.51 | 6.51 |