Basic Information
ID: ALA3734189
Type: Functional
Description: Antagonist activity against rat or human P2X3 receptor expressed in HEK293/1321N1 cells assessed as inhibition of alpha,beta-meATP/ATP-induced calcium influx by Fluo-4 dye based FLIPR assay
Activity Charts
Bioactivity
Activity Types for Assay ALA3734189
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 479.29 | 5.24 | 5.24 |
| 444.85 | 4.59 | 4.59 |
| 521.02 | 4.85 | 4.85 |
| 464.91 | 3.60 | 3.60 |
| 488.90 | 4.51 | 4.51 |
| 414.51 | 3.46 | 3.46 |
| 450.49 | 4.09 | 4.09 |
| 416.49 | 2.77 | 2.77 |
| 430.51 | 3.16 | 3.16 |
| 468.48 | 4.17 | 4.17 |
| 430.51 | 3.42 | 3.42 |
| 390.88 | 3.88 | 3.88 |
| 390.88 | 3.88 | 3.88 |
| 356.43 | 3.23 | 3.23 |
| 396.50 | 4.10 | 4.10 |
| 386.46 | 2.51 | 2.51 |
| 425.32 | 4.53 | 4.53 |
| 384.49 | 3.79 | 3.79 |
| 450.93 | 3.50 | 3.50 |
| 436.90 | 3.11 | 3.11 |
| 380.46 | 3.70 | 3.70 |
| 395.47 | 3.48 | 3.48 |
| 396.45 | 3.97 | 3.97 |
| 371.45 | 2.93 | 2.93 |
| 436.52 | 3.72 | 3.72 |
| 444.50 | 3.25 | 3.25 |
| 443.51 | 2.65 | 2.65 |
| 471.57 | 3.25 | 3.25 |
| 415.89 | 3.82 | 3.82 |
| 391.87 | 3.27 | 3.27 |
| 454.46 | 3.78 | 3.78 |
| 474.87 | 4.12 | 4.12 |
| 387.46 | 4.28 | 4.28 |
| 415.57 | 4.86 | 4.86 |
| 456.94 | 4.07 | 4.07 |
| 442.91 | 3.76 | 3.76 |
| 477.36 | 4.41 | 4.41 |
| 422.50 | 3.41 | 3.41 |
| 402.46 | 2.21 | 2.21 |
| 495.37 | 4.74 | 4.74 |
| 394.48 | 4.01 | 4.01 |
| 421.89 | 3.54 | 3.54 |
| 401.47 | 3.19 | 3.19 |
| 447.56 | 3.54 | 3.54 |
| 417.47 | 2.16 | 2.16 |
| 399.50 | 3.74 | 3.74 |
| 470.91 | 4.43 | 4.43 |
| 454.58 | 3.98 | 3.98 |
| 468.48 | 4.17 | 4.17 |
| 468.48 | 4.17 | 4.17 |
| 385.48 | 3.49 | 3.49 |
| 385.48 | 3.49 | 3.49 |
| 387.45 | 2.63 | 2.63 |
| 407.87 | 2.98 | 2.98 |
| 436.47 | 3.70 | 3.70 |
| 467.98 | 3.89 | 3.89 |
| 456.88 | 4.04 | 4.04 |
| 421.89 | 2.81 | 2.81 |
| 401.47 | 2.46 | 2.46 |
| 405.89 | 3.84 | 3.84 |
| 467.98 | 3.89 | 3.89 |
| 510.52 | 4.74 | 4.74 |
| 437.89 | 2.51 | 2.51 |
| 407.48 | 3.77 | 3.77 |
| 406.49 | 4.38 | 4.38 |
| 394.48 | 4.31 | 4.31 |
| 399.45 | 3.56 | 3.56 |
| 413.48 | 4.12 | 4.12 |
| 427.90 | 4.12 | 4.12 |
| 371.45 | 3.18 | 3.18 |
| 421.51 | 4.34 | 4.34 |
| 401.47 | 3.19 | 3.19 |
| 482.01 | 4.45 | 4.45 |
| 413.48 | 4.12 | 4.12 |
| 413.48 | 4.12 | 4.12 |
| 461.59 | 4.10 | 4.10 |
| 406.49 | 4.38 | 4.38 |
| 482.01 | 4.45 | 4.45 |
| 482.01 | 4.45 | 4.45 |
| 421.51 | 4.34 | 4.34 |
| 421.51 | 4.34 | 4.34 |
| 424.43 | 4.25 | 4.25 |
| 489.30 | 4.70 | 4.70 |
| 450.47 | 4.81 | 4.81 |
| 444.85 | 4.59 | 4.59 |
| 478.40 | 4.96 | 4.96 |
| 503.33 | 5.26 | 5.26 |
| 438.46 | 4.81 | 4.81 |
| 458.88 | 5.15 | 5.15 |
| 428.39 | 4.08 | 4.08 |
| 410.40 | 3.94 | 3.94 |
| 458.88 | 4.90 | 4.90 |
| 419.92 | 3.64 | 3.64 |
| 406.88 | 3.58 | 3.58 |
| 451.33 | 3.69 | 3.69 |
| 386.46 | 3.24 | 3.24 |