Basic Information
ID: ALA3734216
Type: Functional
Description: Increase in insulin release in mouse BetaTC6 cells assessed as relative insulin release activity at 10 uM incubated for 2 to 4 hrs by FRET based HTRF assay relative to sunitinib
Organism: Mus musculus
Cell type: Beta-TC6
Activity Charts
Bioactivity
Activity Types for Assay ALA3734216
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 311.39 | 2.41 | 2.41 |
| 237.26 | 2.33 | 2.33 |
| 295.35 | 2.14 | 2.14 |
| 489.58 | 5.24 | 5.24 |
| 239.28 | 2.80 | 2.80 |
| 209.25 | 2.70 | 2.70 |
| 278.32 | 2.29 | 2.29 |
| 288.33 | 1.77 | 1.77 |
| 239.28 | 2.80 | 2.80 |
| 241.32 | 3.12 | 3.12 |
| 282.30 | 1.12 | 1.12 |
| 332.36 | 3.48 | 3.48 |
| 365.42 | 2.83 | 2.83 |
| 348.36 | 3.18 | 3.18 |
| 346.37 | 3.23 | 3.23 |
| 328.38 | 3.09 | 3.09 |
| 281.34 | 2.86 | 2.86 |
| 431.50 | 3.07 | 3.07 |
| 366.45 | 4.09 | 4.09 |
| 417.47 | 3.72 | 3.72 |
| 316.79 | 3.23 | 3.23 |
| 362.39 | 3.48 | 3.48 |
| 385.43 | 3.98 | 3.98 |
| 407.43 | 3.80 | 3.80 |
| 478.58 | 2.73 | 2.73 |
| 380.84 | 4.38 | 4.38 |
| 375.41 | 4.11 | 4.11 |
| 296.33 | 2.92 | 2.92 |
| 322.37 | 3.32 | 3.32 |
| 400.49 | 3.28 | 3.28 |
| 365.44 | 4.60 | 4.60 |
| 429.48 | 3.57 | 3.57 |
| 311.18 | 2.21 | 2.21 |
| 309.37 | 2.57 | 2.57 |
| 346.39 | 3.72 | 3.72 |
| 369.43 | 4.50 | 4.50 |
| 390.44 | 4.03 | 4.03 |
| 298.35 | 2.20 | 2.20 |
| 328.37 | 2.21 | 2.21 |
| 340.23 | 1.63 | 1.63 |
| 356.43 | 2.84 | 2.84 |
| 361.41 | 3.42 | 3.42 |
| 433.51 | 4.10 | 4.10 |
| 295.35 | 2.62 | 2.62 |
| 344.42 | 4.33 | 4.33 |
| 442.57 | 3.92 | 3.92 |
| 232.29 | 1.56 | 1.56 |
| 240.27 | 2.14 | 2.14 |
| 294.36 | 1.54 | 1.54 |
| 241.32 | 3.12 | 3.12 |
| 221.26 | 2.90 | 2.90 |
| 239.28 | 2.72 | 2.72 |
| 220.24 | 2.27 | 2.27 |
| 237.26 | 2.60 | 2.60 |
| 314.35 | 3.16 | 3.16 |
| 315.33 | 3.79 | 3.79 |
| 333.32 | 3.93 | 3.93 |
| 302.34 | 2.95 | 2.95 |
| 262.27 | 3.05 | 3.05 |
| 278.34 | 3.52 | 3.52 |
| 329.36 | 3.42 | 3.42 |
| 353.78 | 4.86 | 4.86 |
| 413.84 | 4.88 | 4.88 |
| 385.35 | 4.97 | 4.97 |
| 398.34 | 4.06 | 4.06 |
| 363.44 | 3.39 | 3.39 |
| 334.35 | 3.53 | 3.53 |
| 320.78 | 4.30 | 4.30 |
| 365.82 | 4.73 | 4.73 |
| 349.82 | 5.03 | 5.03 |
| 335.79 | 4.73 | 4.73 |
| 305.31 | 3.91 | 3.91 |
| 338.37 | 4.32 | 4.32 |
| 344.42 | 3.62 | 3.62 |
| 303.33 | 2.35 | 2.35 |
| 393.45 | 5.35 | 5.35 |
| 340.31 | 4.48 | 4.48 |
| 355.32 | 4.79 | 4.79 |
| 303.29 | 4.29 | 4.29 |
| 401.34 | 4.68 | 4.68 |
| 364.36 | 3.36 | 3.36 |
| 413.48 | 3.86 | 3.86 |
| 372.38 | 3.75 | 3.75 |
| 406.47 | 3.43 | 3.43 |
| 329.36 | 3.24 | 3.24 |
| 320.42 | 4.19 | 4.19 |
| 329.79 | 4.92 | 4.92 |
| 323.38 | 3.84 | 3.84 |
| 311.80 | 4.78 | 4.78 |
| 396.45 | 3.50 | 3.50 |
| 301.35 | 2.96 | 2.96 |
| 333.35 | 1.96 | 1.96 |
| 315.33 | 3.79 | 3.79 |
| 328.38 | 4.02 | 4.02 |
| 315.38 | 4.38 | 4.38 |
| 296.33 | 3.19 | 3.19 |
| 276.34 | 2.31 | 2.31 |
| 364.43 | 3.43 | 3.43 |
| 349.78 | 4.45 | 4.45 |
| 305.29 | 3.39 | 3.39 |
| 343.35 | 2.26 | 2.26 |
| 293.28 | 1.47 | 1.47 |
| 319.32 | 2.53 | 2.53 |
| 372.38 | 3.15 | 3.15 |
| 357.42 | 3.29 | 3.29 |
| 332.36 | 3.48 | 3.48 |
| 356.31 | 4.36 | 4.36 |
| 302.34 | 2.95 | 2.95 |
| 364.33 | 4.21 | 4.21 |
| 364.41 | 5.25 | 5.25 |
| 315.38 | 3.52 | 3.52 |
| 314.39 | 4.58 | 4.58 |
| 306.76 | 4.11 | 4.11 |
| 374.44 | 4.15 | 4.15 |
| 409.47 | 3.48 | 3.48 |
| 349.37 | 4.22 | 4.22 |
| 402.45 | 3.78 | 3.78 |
| 356.39 | 3.21 | 3.21 |
| 337.40 | 4.14 | 4.14 |
| 386.33 | 4.37 | 4.37 |
| 433.41 | 4.37 | 4.37 |
| 409.37 | 4.70 | 4.70 |
| 361.35 | 5.02 | 5.02 |
| 379.34 | 4.69 | 4.69 |
| 320.78 | 4.30 | 4.30 |
| 349.78 | 4.45 | 4.45 |
| 306.76 | 4.11 | 4.11 |
| 306.76 | 4.11 | 4.11 |
| 295.73 | 4.31 | 4.31 |
| 362.82 | 4.68 | 4.68 |
| 307.74 | 3.51 | 3.51 |
| 307.74 | 3.51 | 3.51 |
| 356.82 | 5.26 | 5.26 |
| 312.33 | 3.64 | 3.64 |
| 305.31 | 3.91 | 3.91 |
| 338.37 | 4.32 | 4.32 |
| 429.40 | 5.11 | 5.11 |
| 467.50 | 4.76 | 4.76 |
| 452.44 | 4.55 | 4.55 |
| 410.40 | 4.78 | 4.78 |
| 355.32 | 4.06 | 4.06 |
| 415.50 | 3.53 | 3.53 |
| 335.34 | 3.92 | 3.92 |
| 331.38 | 4.09 | 4.09 |
| 351.36 | 3.68 | 3.68 |
| 291.31 | 3.66 | 3.66 |
| 267.31 | 3.72 | 3.72 |
| 297.32 | 3.33 | 3.33 |
| 345.40 | 4.39 | 4.39 |
| 372.43 | 3.09 | 3.09 |
| 328.38 | 3.47 | 3.47 |
| 363.45 | 3.36 | 3.36 |
| 321.41 | 3.59 | 3.59 |
| 330.77 | 4.31 | 4.31 |
| 317.38 | 4.00 | 4.00 |
| 321.37 | 2.62 | 2.62 |
| 322.39 | 3.84 | 3.84 |
| 373.46 | 0.93 | 0.93 |
| 312.79 | 4.17 | 4.17 |
| 308.37 | 3.53 | 3.53 |
| 329.39 | 4.07 | 4.07 |
| 432.52 | 4.41 | 4.41 |
| 406.92 | 5.05 | 5.05 |
| 467.57 | 3.83 | 3.83 |
| 456.55 | 4.14 | 4.14 |
| 429.52 | 3.75 | 3.75 |
| 380.41 | 3.96 | 3.96 |
| 437.51 | 3.30 | 3.30 |
| 449.52 | 3.39 | 3.39 |
| 369.38 | 3.72 | 3.72 |
| 313.32 | 3.60 | 3.60 |
| 394.44 | 3.71 | 3.71 |
| 288.31 | 3.16 | 3.16 |
| 302.34 | 2.95 | 2.95 |
| 350.40 | 2.86 | 2.86 |
| 427.29 | 4.89 | 4.89 |
| 415.50 | 3.65 | 3.65 |
| 364.45 | 4.12 | 4.12 |
| 397.44 | 4.07 | 4.07 |
| 450.50 | 5.38 | 5.38 |
| 364.43 | 3.65 | 3.65 |
| 362.39 | 2.32 | 2.32 |
| 326.41 | 3.77 | 3.77 |
| 344.37 | 3.66 | 3.66 |
| 357.42 | 3.71 | 3.71 |
| 329.36 | 3.23 | 3.23 |
| 386.41 | 3.87 | 3.87 |
| 387.40 | 4.05 | 4.05 |
| 372.43 | 3.38 | 3.38 |
| 334.38 | 3.34 | 3.34 |
| 358.40 | 3.52 | 3.52 |
| 379.37 | 3.44 | 3.44 |
| 352.39 | 3.78 | 3.78 |
| 364.43 | 3.65 | 3.65 |
| 416.53 | 3.85 | 3.85 |
| 443.56 | 3.27 | 3.27 |
| 357.46 | 4.20 | 4.20 |
| 330.39 | 3.83 | 3.83 |
| 442.57 | 3.81 | 3.81 |
| 401.47 | 2.85 | 2.85 |
| 344.42 | 3.62 | 3.62 |
| 345.41 | 3.53 | 3.53 |
| 428.54 | 3.42 | 3.42 |
| 401.47 | 2.85 | 2.85 |
| 427.51 | 3.60 | 3.60 |
| 357.42 | 3.23 | 3.23 |
| 385.47 | 3.83 | 3.83 |
| 348.84 | 4.78 | 4.78 |
| 407.50 | 3.50 | 3.50 |
| 277.35 | 4.12 | 4.12 |
| 289.31 | 4.20 | 4.20 |
| 277.35 | 4.12 | 4.12 |
| 354.41 | 3.96 | 3.96 |
| 315.33 | 3.79 | 3.79 |
| 321.36 | 3.85 | 3.85 |
| 359.39 | 4.19 | 4.19 |
| 349.78 | 4.45 | 4.45 |
| 333.32 | 3.93 | 3.93 |
| 329.36 | 4.10 | 4.10 |
| 321.36 | 3.85 | 3.85 |
| 395.42 | 4.04 | 4.04 |
| 375.38 | 3.81 | 3.81 |
| 331.34 | 2.77 | 2.77 |
| 373.41 | 4.58 | 4.58 |
| 364.41 | 5.25 | 5.25 |
| 316.36 | 3.78 | 3.78 |
| 278.34 | 3.52 | 3.52 |
| 357.42 | 3.29 | 3.29 |
| 328.40 | 4.67 | 4.67 |
| 318.41 | 4.18 | 4.18 |
| 365.42 | 2.83 | 2.83 |
| 267.31 | 3.72 | 3.72 |
| 329.79 | 4.92 | 4.92 |
| 364.43 | 2.85 | 2.85 |
| 283.38 | 4.19 | 4.19 |
| 337.40 | 4.14 | 4.14 |
| 321.77 | 4.42 | 4.42 |
| 413.53 | 4.30 | 4.30 |
| 370.41 | 3.66 | 3.66 |
| 291.31 | 2.50 | 2.50 |
| 387.44 | 4.48 | 4.48 |
| 377.83 | 4.73 | 4.73 |
| 357.41 | 4.39 | 4.39 |
| 377.83 | 4.73 | 4.73 |
| 349.42 | 4.14 | 4.14 |
| 373.41 | 3.57 | 3.57 |
| 371.44 | 4.70 | 4.70 |
| 296.33 | 3.93 | 3.93 |
| 302.36 | 4.00 | 4.00 |
| 330.78 | 4.59 | 4.59 |
| 326.36 | 3.43 | 3.43 |
| 302.36 | 4.00 | 4.00 |
| 460.54 | 3.24 | 3.24 |
| 402.50 | 3.83 | 3.83 |
| 315.38 | 3.52 | 3.52 |
| 320.42 | 4.19 | 4.19 |
| 344.42 | 3.62 | 3.62 |
| 320.42 | 4.19 | 4.19 |
| 374.44 | 4.15 | 4.15 |
| 306.76 | 4.11 | 4.11 |
| 311.80 | 4.78 | 4.78 |
| 311.80 | 4.78 | 4.78 |
| 380.81 | 4.81 | 4.81 |
| 313.72 | 4.45 | 4.45 |
| 356.31 | 4.36 | 4.36 |
| 442.40 | 3.68 | 3.68 |
| 441.49 | 3.18 | 3.18 |
| 481.48 | 4.35 | 4.35 |
| 431.93 | 4.10 | 4.10 |
| 450.55 | 3.94 | 3.94 |
| 502.62 | 5.06 | 5.06 |
| 335.79 | 4.21 | 4.21 |
| 331.38 | 3.56 | 3.56 |
| 307.38 | 4.13 | 4.13 |
| 317.35 | 3.05 | 3.05 |
| 343.41 | 4.98 | 4.98 |
| 321.77 | 4.42 | 4.42 |
| 313.36 | 4.27 | 4.27 |
| 385.47 | 3.52 | 3.52 |
| 321.77 | 4.42 | 4.42 |
| 318.34 | 3.17 | 3.17 |
| 293.35 | 3.83 | 3.83 |
| 347.37 | 3.79 | 3.79 |
| 335.34 | 3.92 | 3.92 |
| 291.31 | 3.15 | 3.15 |
| 370.24 | 4.86 | 4.86 |
| 412.49 | 4.23 | 4.23 |
| 301.35 | 3.56 | 3.56 |
| 347.44 | 4.28 | 4.28 |
| 345.40 | 3.95 | 3.95 |
| 307.38 | 3.62 | 3.62 |
| 359.43 | 4.34 | 4.34 |
| 400.49 | 3.22 | 3.22 |
| 333.35 | 2.87 | 2.87 |
| 345.36 | 2.57 | 2.57 |
| 304.33 | 3.78 | 3.78 |
| 289.31 | 4.20 | 4.20 |
| 333.32 | 3.93 | 3.93 |
| 373.44 | 3.61 | 3.61 |
| 323.76 | 4.86 | 4.86 |
| 319.34 | 3.69 | 3.69 |
| 295.34 | 4.26 | 4.26 |
| 419.49 | 3.50 | 3.50 |
| 446.51 | 2.92 | 2.92 |
| 416.49 | 2.92 | 2.92 |
| 361.36 | 3.51 | 3.51 |
| 361.40 | 4.18 | 4.18 |
| 333.35 | 2.75 | 2.75 |
| 321.34 | 2.51 | 2.51 |
| 452.56 | 4.24 | 4.24 |
| 411.47 | 3.28 | 3.28 |
| 370.41 | 4.27 | 4.27 |
| 367.41 | 3.65 | 3.65 |
| 423.52 | 3.95 | 3.95 |
| 456.53 | 5.23 | 5.23 |
| 303.34 | 4.51 | 4.51 |
| 291.38 | 4.43 | 4.43 |
| 351.79 | 4.43 | 4.43 |
| 343.43 | 4.34 | 4.34 |
| 314.35 | 3.66 | 3.66 |
| 331.35 | 4.41 | 4.41 |
| 427.51 | 3.56 | 3.56 |
| 319.39 | 4.33 | 4.33 |
| 320.42 | 4.19 | 4.19 |
| 278.34 | 3.52 | 3.52 |
| 283.38 | 4.19 | 4.19 |
| 333.44 | 5.34 | 5.34 |
| 293.35 | 3.83 | 3.83 |
| 361.35 | 5.02 | 5.02 |
| 303.39 | 4.63 | 4.63 |
| 364.43 | 2.85 | 2.85 |
| 311.80 | 4.78 | 4.78 |
| 307.38 | 3.62 | 3.62 |
| 364.43 | 2.85 | 2.85 |
| 283.38 | 4.19 | 4.19 |
| 370.46 | 3.50 | 3.50 |
| 337.40 | 4.14 | 4.14 |
| 293.36 | 3.10 | 3.10 |
| 335.43 | 4.91 | 4.91 |
| 441.54 | 2.91 | 2.91 |
| 434.50 | 5.56 | 5.56 |
| 348.43 | 3.83 | 3.83 |
| 399.45 | 3.72 | 3.72 |
| 395.47 | 4.26 | 4.26 |
| 402.48 | 4.22 | 4.22 |
| 480.62 | 4.49 | 4.49 |
| 374.44 | 4.15 | 4.15 |
| 389.46 | 4.87 | 4.87 |
| 276.30 | 2.19 | 2.19 |
| 331.40 | 4.01 | 4.01 |
| 412.45 | 4.64 | 4.64 |
| 368.40 | 4.33 | 4.33 |
| 366.42 | 4.93 | 4.93 |
| 375.44 | 5.10 | 5.10 |
| 415.48 | 3.98 | 3.98 |