Basic Information
ID: ALA3742872
Type: Binding
Description: Inhibition of human TNF assessed as reduction in TNF-induced cell death of actinomycin D activated mouse L929 cells preincubated for 30 mins followed by cell addition measured after 18 to 24 hrs by crystal violet staining based spectrophotometric analysis
Organism: Homo sapiens
Cell type: L929
Activity Charts
Bioactivity
Activity Types for Assay ALA3742872
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 547.62 | 6.94 | 6.94 |
| 545.61 | 6.69 | 6.69 |
| 533.59 | 6.63 | 6.63 |
| 531.58 | 6.38 | 6.38 |
| 575.59 | 6.22 | 6.22 |
| 573.57 | 5.97 | 5.97 |
| 524.53 | 4.49 | 4.49 |
| 522.52 | 4.24 | 4.24 |
| 494.55 | 4.16 | 4.16 |
| 492.54 | 3.92 | 3.92 |
| 543.60 | 3.83 | 3.83 |
| 541.59 | 3.58 | 3.58 |
| 588.60 | 3.74 | 3.74 |
| 586.58 | 3.49 | 3.49 |
| 558.62 | 3.41 | 3.41 |
| 556.60 | 3.17 | 3.17 |
| 497.58 | 4.19 | 4.19 |
| 525.63 | 4.88 | 4.88 |
| 475.57 | 3.72 | 3.72 |
| 465.54 | 2.75 | 2.75 |
| 493.56 | 3.86 | 3.86 |
| 481.60 | 3.78 | 3.78 |
| 523.61 | 4.63 | 4.63 |
| 527.55 | 6.40 | 6.40 |
| 467.45 | 4.27 | 4.27 |
| 477.49 | 5.25 | 5.25 |
| 592.53 | 5.51 | 5.51 |
| 590.51 | 5.26 | 5.26 |
| 542.49 | 5.54 | 5.54 |
| 507.55 | 3.50 | 3.50 |
| 509.57 | 2.97 | 2.97 |
| 567.51 | 4.15 | 4.15 |
| 396.38 | 2.81 | 2.81 |
| 384.42 | 2.74 | 2.74 |
| 531.53 | 5.71 | 5.71 |
| 576.53 | 5.62 | 5.62 |
| 513.56 | 6.76 | 6.76 |
| 558.56 | 6.67 | 6.67 |
| 463.50 | 5.61 | 5.61 |
| 529.57 | 3.53 | 3.53 |
| 525.63 | 4.97 | 4.97 |
| 461.54 | 3.43 | 3.43 |