Basic Information
ID: ALA3743381
Type: Binding
Description: Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured every 1 sec for 60 secs followed by 3 sec intervals for 4 mins by FLIPR Ca2+ assay in presence of ionomycin
Organism: Homo sapiens
Cell type: 1321-N1
Activity Charts
Bioactivity
Activity Types for Assay ALA3743381
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 477.30 | 3.91 | 3.91 |
| 430.30 | 4.07 | 4.07 |
| 431.29 | 4.53 | 4.53 |
| 384.41 | 4.21 | 4.21 |
| 477.30 | 3.91 | 3.91 |
| 477.30 | 3.91 | 3.91 |
| 435.70 | 5.17 | 5.17 |
| 435.70 | 5.17 | 5.17 |
| 483.72 | 4.67 | 4.67 |
| 449.28 | 4.67 | 4.67 |
| 437.24 | 4.80 | 4.80 |
| 453.70 | 5.31 | 5.31 |
| 418.85 | 4.22 | 4.22 |
| 418.85 | 3.28 | 3.28 |
| 449.28 | 3.73 | 3.73 |
| 464.47 | 3.50 | 3.50 |
| 436.42 | 3.18 | 3.18 |
| 537.55 | 1.32 | 1.32 |
| 432.46 | 3.50 | 3.50 |
| 368.41 | 3.58 | 3.58 |
| 408.43 | 2.60 | 2.60 |