Basic Information
ID: ALA3744252
Type: Binding
Description: Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassay
Format: BAO_0000221
Organism: Homo sapiens
Tissue: Blood
Target: Prostanoid EP4 receptor(ALA1836)
Document: ALA3739413
Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3744252
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 491.62 | 4.14 | 4.14 |
| 352.44 | 5.77 | 5.77 |
| 396.45 | 5.47 | 5.47 |
| 396.45 | 5.47 | 5.47 |
| 426.47 | 4.96 | 4.96 |
| 426.47 | 4.96 | 4.96 |
| 395.46 | 6.07 | 6.07 |
| 395.46 | 6.07 | 6.07 |
| 425.48 | 5.57 | 5.57 |
| 425.48 | 5.57 | 5.57 |
| 429.90 | 6.73 | 6.73 |