Basic Information
ID: ALA3745027
Type: Binding
Description: Antagonist activity at P2X7 receptor expressed in LPS/IFNgamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta production at 1 uM after 4 hrs by ELISA
Format: BAO_0000219
Organism: Homo sapiens
Cell type: THP-1
Target: P2X purinoceptor 7(ALA4805)
Document: ALA3739377
Antagonist activity at P2X7 receptor expressed in LPS/IFNgamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta production at 1 uM after 4 hrs by ELISA: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3745027
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 721.86 | 5.13 | 5.13 |
| 569.64 | 3.23 | 3.23 |
| 587.63 | 3.37 | 3.37 |
| 587.63 | 3.37 | 3.37 |
| 583.67 | 3.54 | 3.54 |
| 614.64 | 3.14 | 3.14 |
| 637.64 | 4.25 | 4.25 |
| 583.67 | 3.22 | 3.22 |
| 601.66 | 3.36 | 3.36 |
| 597.65 | 2.75 | 2.75 |
| 715.79 | 4.97 | 4.97 |
| 493.55 | 1.31 | 1.31 |
| 597.65 | 2.86 | 2.86 |
| 611.68 | 2.79 | 2.79 |
| 632.10 | 3.52 | 3.52 |
| 632.10 | 3.52 | 3.52 |
| 632.10 | 3.52 | 3.52 |
| 676.55 | 3.63 | 3.63 |
| 615.64 | 3.00 | 3.00 |
| 650.09 | 3.66 | 3.66 |
| 710.99 | 4.28 | 4.28 |
| 633.63 | 3.14 | 3.14 |
| 666.54 | 4.17 | 4.17 |
| 650.09 | 3.66 | 3.66 |
| 700.10 | 4.54 | 4.54 |
| 577.66 | 2.60 | 2.60 |
| 563.64 | 2.21 | 2.21 |
| 577.66 | 2.60 | 2.60 |
| 563.64 | 2.35 | 2.35 |
| 603.70 | 3.13 | 3.13 |
| 617.73 | 3.52 | 3.52 |
| 655.78 | 3.77 | 3.77 |
| 669.80 | 4.16 | 4.16 |
| 734.67 | 4.28 | 4.28 |
| 683.83 | 4.55 | 4.55 |
| 641.75 | 3.38 | 3.38 |
| 615.71 | 2.99 | 2.99 |
| 629.74 | 3.38 | 3.38 |