Basic Information
ID: ALA3745028
Type: Binding
Description: Antagonist activity at P2X7 receptor expressed in LPS/IFNgamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta production after 4 hrs by ELISA
Format: BAO_0000219
Organism: Homo sapiens
Cell type: THP-1
Target: P2X purinoceptor 7(ALA4805)
Document: ALA3739377
Antagonist activity at P2X7 receptor expressed in LPS/IFNgamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta production after 4 hrs by ELISA: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3745028
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 721.86 | 5.13 | 5.13 |
| 676.55 | 3.63 | 3.63 |
| 666.54 | 4.17 | 4.17 |
| 700.10 | 4.54 | 4.54 |
| 655.78 | 3.77 | 3.77 |
| 669.80 | 4.16 | 4.16 |
| 734.67 | 4.28 | 4.28 |
| 629.74 | 3.38 | 3.38 |