Basic Information
ID: ALA3754944
Type: Binding
Description: Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
Format: BAO_0000221
Organism: Homo sapiens
Tissue: Blood
Target: Prostanoid EP4 receptor(ALA1836)
Document: ALA3751833
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3754944
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 682.63 | 7.18 | 7.18 |
| 491.62 | 4.14 | 4.14 |
| 425.48 | 5.57 | 5.57 |
| 429.90 | 6.73 | 6.73 |
| 389.45 | 4.72 | 4.72 |
| 393.41 | 4.55 | 4.55 |
| 389.45 | 4.72 | 4.72 |
| 393.41 | 4.55 | 4.55 |
| 390.44 | 4.12 | 4.12 |
| 444.41 | 4.83 | 4.83 |
| 390.44 | 4.12 | 4.12 |
| 444.41 | 4.83 | 4.83 |
| 394.86 | 5.28 | 5.28 |