Basic Information
ID: ALA3761678
Type: ADME
Description: Inhibition of microsomal CYP3A4 (unknown origin) using bufuralol/midazolam/diclofinac as substrate assessed as 1-hydroxybufuralol maleate-d9/alpha-hydroxymidazolam-d4/[13C6]-4-hydroxydiclofinac formation at 10 uM pre-incubated for 10 mins before NADPH addition by LC-MS/MS analysis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3761678
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 378.82 | 5.93 | 5.93 |
| 495.45 | 5.26 | 5.26 |
| 548.03 | 8.78 | 8.78 |
| 446.89 | 5.19 | 5.19 |
| 447.87 | 4.59 | 4.59 |
| 461.90 | 4.90 | 4.90 |
| 481.43 | 5.02 | 5.02 |
| 467.40 | 4.62 | 4.62 |