Basic Information
ID: ALA3776325
Type: Binding
Description: Inhibition of N-terminal His6-tagged KDM4C (1 to 352 residues) (unknown origin) expressed in Escherichia coli Rosetta 2(DE3)pLysS using biotinylated histone H3 (1 to 21 residues) lysine 9 trimethylated peptide/2 uM alpha-ketoglutarate as substrate/cofactor measured after 45 mins by TR-FRET assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3776325
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 167.12 | 0.48 | 0.48 |
| 189.17 | -0.56 | -0.56 |
| 230.22 | 1.05 | 1.05 |
| 195.17 | 1.05 | 1.05 |
| 247.25 | 0.83 | 0.83 |
| 247.25 | 0.83 | 0.83 |
| 247.25 | 1.44 | 1.44 |
| 225.20 | 0.68 | 0.68 |
| 188.23 | 0.56 | 0.56 |
| 240.28 | 1.40 | 1.40 |
| 234.21 | 1.43 | 1.43 |
| 252.27 | -0.64 | -0.64 |
| 241.25 | 2.65 | 2.65 |
| 212.23 | 0.58 | 0.58 |
| 228.63 | 0.94 | 0.94 |
| 234.22 | 0.34 | 0.34 |
| 322.16 | 3.47 | 3.47 |
| 287.27 | 2.43 | 2.43 |
| 230.22 | 1.73 | 1.73 |
| 244.25 | 2.04 | 2.04 |
| 228.25 | 2.41 | 2.41 |
| 350.33 | 3.11 | 3.11 |
| 350.33 | 3.11 | 3.11 |
| 350.33 | 3.11 | 3.11 |
| 339.31 | 2.70 | 2.70 |
| 348.36 | 3.33 | 3.33 |
| 427.25 | 4.10 | 4.10 |
| 378.38 | 3.34 | 3.34 |
| 378.38 | 3.34 | 3.34 |
| 325.28 | 2.39 | 2.39 |
| 302.29 | 1.74 | 1.74 |
| 240.22 | 2.02 | 2.02 |
| 272.26 | 2.11 | 2.11 |
| 324.34 | 2.50 | 2.50 |
| 364.36 | 3.49 | 3.49 |
| 399.24 | 4.53 | 4.53 |