Basic Information
ID: ALA3776776
Type: Binding
Description: Antagonist activity against 6xHis-MBP-fused human MR LBD domain (732 to 984 amino acid residues) C808S mutant expressed in Escherichia coli BL21(DE3) assessed as inhibition of aldosterone-mediated receptor activation after 16 hrs by luciferase assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3776776
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 289.28 | 3.08 | 3.08 |
| 285.25 | 2.70 | 2.70 |
| 287.26 | 3.47 | 3.47 |
| 287.26 | 3.47 | 3.47 |
| 291.25 | 2.87 | 2.87 |
| 363.36 | 4.88 | 4.88 |
| 304.30 | 2.93 | 2.93 |
| 349.37 | 3.89 | 3.89 |
| 413.43 | 2.95 | 2.95 |
| 358.37 | 4.48 | 4.48 |
| 393.44 | 4.56 | 4.56 |
| 356.40 | 5.44 | 5.44 |
| 358.41 | 5.29 | 5.29 |
| 456.52 | 5.24 | 5.24 |
| 498.55 | 5.07 | 5.07 |
| 511.60 | 4.68 | 4.68 |
| 483.54 | 4.60 | 4.60 |
| 373.38 | 4.64 | 4.64 |
| 440.52 | 5.22 | 5.22 |
| 376.39 | 4.39 | 4.39 |
| 426.43 | 3.58 | 3.58 |
| 515.99 | 3.82 | 3.82 |
| 465.96 | 4.63 | 4.63 |
| 479.94 | 4.27 | 4.27 |
| 470.55 | 5.21 | 5.21 |
| 462.95 | 4.88 | 4.88 |