Basic Information
ID: ALA3776824
Type: ADME
Description: Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated with substrate for 5 mins followed by NADPH addition measured after 20 mins by HPLC analysis
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA3776824
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 394.56 | 5.34 | 5.34 |
| 450.63 | 5.26 | 5.26 |
| 477.65 | 4.97 | 4.97 |