Basic Information
ID: ALA3778237
Type: Binding
Description: Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addition measured after 20 mins by HTRF assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3778237
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 475.36 | 4.43 | 4.43 |
| 297.31 | 3.10 | 3.10 |
| 329.33 | 3.54 | 3.54 |
| 311.34 | 3.40 | 3.40 |
| 331.76 | 3.75 | 3.75 |
| 297.31 | 3.10 | 3.10 |
| 311.34 | 3.40 | 3.40 |
| 378.20 | 4.29 | 4.29 |
| 501.51 | 5.54 | 5.54 |
| 296.33 | 2.97 | 2.97 |
| 297.31 | 3.10 | 3.10 |
| 313.31 | 2.80 | 2.80 |
| 376.21 | 3.86 | 3.86 |
| 331.76 | 3.75 | 3.75 |
| 311.34 | 3.40 | 3.40 |
| 315.30 | 3.24 | 3.24 |
| 327.34 | 3.10 | 3.10 |
| 325.37 | 3.66 | 3.66 |
| 365.31 | 4.12 | 4.12 |
| 322.32 | 2.97 | 2.97 |
| 315.30 | 3.24 | 3.24 |
| 327.34 | 3.10 | 3.10 |
| 315.30 | 3.24 | 3.24 |
| 311.34 | 3.40 | 3.40 |
| 315.30 | 3.24 | 3.24 |
| 331.76 | 3.75 | 3.75 |
| 311.34 | 3.40 | 3.40 |
| 333.29 | 3.37 | 3.37 |
| 366.20 | 4.40 | 4.40 |
| 345.79 | 4.06 | 4.06 |
| 333.29 | 3.37 | 3.37 |
| 333.29 | 3.37 | 3.37 |
| 349.75 | 3.89 | 3.89 |
| 329.33 | 3.54 | 3.54 |
| 329.33 | 3.54 | 3.54 |
| 345.79 | 4.06 | 4.06 |
| 345.79 | 4.06 | 4.06 |
| 366.20 | 4.40 | 4.40 |
| 349.75 | 3.89 | 3.89 |
| 311.34 | 3.12 | 3.12 |
| 298.30 | 3.14 | 3.14 |
| 314.37 | 3.50 | 3.50 |
| 323.35 | 3.05 | 3.05 |
| 337.38 | 3.44 | 3.44 |