Basic Information
ID: ALA3784372
Type: ADME
Description: Drug metabolism in rat liver microsomes assessed as CYP2E1 mediated metabolite M4 formation at 10 uM preincubated for 5 mins followed by addition of NADPH measured after 120 mins by HPLC-TIC chromatography in presence of CYP1A2 inhibitor alpha-naphthoflavone, CYP2C8 inhibitor quercetin, CYP2C9 inhibitor sulfaphenazole, CYP2C19 inhibitor ticlopidine, CYP2D6 inhibitor quinidine, CYP3A inhibitor ketoconazole
Organism: Rattus norvegicus
Tissue: Liver
Subcellular Fraction: Microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA3784372
Drug metabolism
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 861.86 | 3.80 | 3.80 |