Basic Information
ID: ALA3789901
Type: Functional
Description: Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calcium mobilization pre-incubated for 2.5 mins before glutamate stimulation for 1 min
Organism: Homo sapiens
Cell type: T-Rex293
Activity Charts
Bioactivity
Activity Types for Assay ALA3789901
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 398.78 | 4.43 | 4.43 |
| 446.68 | 5.09 | 5.09 |
| 364.33 | 3.78 | 3.78 |
| 378.36 | 4.09 | 4.09 |
| 386.84 | 4.17 | 4.17 |
| 386.84 | 4.17 | 4.17 |
| 398.80 | 4.44 | 4.44 |
| 354.79 | 4.75 | 4.75 |
| 366.80 | 4.65 | 4.65 |
| 352.82 | 5.01 | 5.01 |
| 366.80 | 4.71 | 4.71 |
| 352.82 | 5.19 | 5.19 |
| 353.81 | 4.41 | 4.41 |
| 368.82 | 5.02 | 5.02 |
| 369.81 | 4.42 | 4.42 |
| 380.83 | 4.70 | 4.70 |
| 366.85 | 5.06 | 5.06 |
| 401.25 | 5.31 | 5.31 |
| 401.25 | 5.31 | 5.31 |
| 401.25 | 5.31 | 5.31 |
| 380.83 | 4.96 | 4.96 |
| 384.79 | 4.79 | 4.79 |
| 445.70 | 5.42 | 5.42 |
| 434.80 | 5.67 | 5.67 |
| 391.81 | 4.53 | 4.53 |
| 396.83 | 4.66 | 4.66 |
| 367.79 | 4.05 | 4.05 |
| 367.79 | 4.05 | 4.05 |
| 368.78 | 3.44 | 3.44 |
| 394.86 | 5.39 | 5.39 |
| 332.36 | 4.00 | 4.00 |
| 366.80 | 4.65 | 4.65 |
| 366.80 | 4.65 | 4.65 |
| 401.25 | 5.31 | 5.31 |
| 435.69 | 5.96 | 5.96 |
| 435.69 | 5.96 | 5.96 |
| 350.35 | 4.14 | 4.14 |
| 384.79 | 4.79 | 4.79 |
| 384.79 | 4.79 | 4.79 |
| 377.83 | 4.46 | 4.46 |
| 412.28 | 5.11 | 5.11 |
| 412.28 | 5.11 | 5.11 |
| 398.25 | 4.80 | 4.80 |
| 432.69 | 5.45 | 5.45 |
| 432.69 | 5.45 | 5.45 |
| 383.86 | 4.52 | 4.52 |
| 418.31 | 5.17 | 5.17 |
| 418.31 | 5.17 | 5.17 |
| 394.81 | 4.22 | 4.22 |
| 408.84 | 4.15 | 4.15 |
| 380.83 | 5.10 | 5.10 |