Basic Information
ID: ALA3801493
Type: Binding
Description: Inhibition of recombinant human C-terminal His6-tagged soluble COMT transfected in Escherichia coli BL21-Gold (DE3) using SAM/dopamine as substrate preincubated for 2 hrs followed by substrate addition measured after 25 mins by SAC TAMRA tracer-based fluorescence polarization assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Catechol O-methyltransferase(ALA2023)
Document: ALA3797074
Inhibition of recombinant human C-terminal His6-tagged soluble COMT transfected in Escherichia coli BL21-Gold (DE3) using SAM/dopamine as substrate preincubated for 2 hrs followed by substrate addition measured after 25 mins by SAC TAMRA tracer-based fluorescence polarization assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3801493
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 265.27 | 2.00 | 2.00 |
| 271.30 | 2.06 | 2.06 |
| 264.28 | 2.61 | 2.61 |
| 264.28 | 2.61 | 2.61 |
| 282.27 | 2.74 | 2.74 |
| 264.28 | 2.61 | 2.61 |
| 264.28 | 2.61 | 2.61 |
| 238.25 | 2.09 | 2.09 |
| 242.24 | 0.89 | 0.89 |