Basic Information
ID: ALA3801549
Type: ADME
Description: Inhibition of CYP3A4 in human liver microsomes using testosterone and midazolam as substrate preincubated for 30 mins followed substrate addition by LC-MS/MS analysis
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA3801549
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 453.53 | 2.88 | 2.88 |
| 447.50 | 2.54 | 2.54 |
| 420.40 | 1.33 | 1.33 |
| 438.39 | 1.47 | 1.47 |
| 420.40 | 1.33 | 1.33 |
| 384.42 | 1.05 | 1.05 |
| 402.41 | 1.19 | 1.19 |
| 402.41 | 1.19 | 1.19 |
| 456.38 | 1.61 | 1.61 |
| 438.39 | 1.47 | 1.47 |
| 420.40 | 1.54 | 1.54 |
| 477.53 | 2.55 | 2.55 |
| 415.45 | 1.19 | 1.19 |
| 424.89 | 1.98 | 1.98 |