Assay Report Card

Basic Information

ID: ALA3803473

Type: Functional

Description: Agonist activity at human recombinant S1PR1 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount analysis

Organism: Homo sapiens

Cell type: CHO

Activity Charts

Bioactivity

Activity Types for Assay ALA3803473

EC50

Total(65)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
496.61	3.73	3.73
497.60	2.67	2.67
497.60	2.67	2.67
479.63	4.12	4.12
511.62	2.67	2.67
454.57	3.55	3.55
483.57	1.89	1.89
511.62	2.67	2.67
525.65	2.91	2.91
525.65	3.06	3.06
509.61	2.42	2.42
482.58	2.49	2.49
496.61	2.88	2.88
510.64	3.27	3.27
524.66	3.66	3.66
524.66	3.52	3.52
538.69	3.77	3.77
552.72	4.16	4.16
552.72	4.33	4.33
510.64	3.18	3.18
454.53	1.84	1.84
482.58	2.62	2.62
496.61	2.87	2.87
482.58	2.49	2.49
496.61	2.88	2.88
510.64	3.27	3.27
524.66	3.66	3.66
524.66	3.52	3.52
510.64	3.18	3.18
524.66	3.52	3.52
482.58	2.49	2.49
496.61	2.88	2.88
524.66	3.66	3.66
524.66	3.52	3.52
510.64	3.27	3.27
508.62	3.03	3.03
510.64	3.18	3.18
468.55	2.18	2.18
454.53	1.84	1.84
496.61	2.80	2.80
482.58	2.49	2.49
496.61	2.75	2.75
510.64	3.14	3.14
524.66	3.53	3.53
522.65	3.28	3.28
488.61	2.55	2.55
502.64	2.94	2.94
516.66	3.33	3.33
530.69	3.72	3.72
530.69	3.58	3.58
518.64	1.92	1.92
545.71	2.49	2.49
474.58	2.21	2.21
516.66	3.24	3.24
460.56	1.90	1.90
474.58	2.29	2.29
488.61	2.68	2.68
474.58	2.25	2.25
488.61	2.64	2.64
502.64	2.81	2.81
530.69	3.59	3.59
502.64	2.86	2.86
530.69	3.64	3.64
544.72	3.89	3.89
459.52	2.31	2.31