Basic Information
ID: ALA3820948
Type: Binding
Description: Inhibition of human recombinant N-terminal 6-His-tagged PAK1 kinase domain (249 to 545 residues) expressed in Escherichia coli BL21(DE3) assessed as phosphorylation of coumarin labeled FRET peptide substrate at Ser/Thr19 preincubated for 10 mins followed by ATP addition measured after 60 mins by Z'-LYTE assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Serine/threonine-protein kinase PAK 1(ALA4600)
Document: ALA3817726
Inhibition of human recombinant N-terminal 6-His-tagged PAK1 kinase domain (249 to 545 residues) expressed in Escherichia coli BL21(DE3) assessed as phosphorylation of coumarin labeled FRET peptide substrate at Ser/Thr19 preincubated for 10 mins followed by ATP addition measured after 60 mins by Z'-LYTE assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3820948
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 518.07 | 5.04 | 5.04 |
| 492.97 | 3.22 | 3.22 |
| 434.93 | 3.87 | 3.87 |
| 343.82 | 2.50 | 2.50 |
| 426.91 | 2.63 | 2.63 |
| 441.92 | 2.37 | 2.37 |
| 439.91 | 1.99 | 1.99 |
| 436.90 | 2.65 | 2.65 |
| 450.93 | 2.96 | 2.96 |
| 451.92 | 2.36 | 2.36 |
| 451.92 | 2.36 | 2.36 |
| 421.89 | 3.63 | 3.63 |
| 463.93 | 3.40 | 3.40 |
| 437.89 | 2.61 | 2.61 |
| 451.91 | 3.26 | 3.26 |
| 493.95 | 3.03 | 3.03 |
| 486.91 | 3.21 | 3.21 |
| 526.98 | 3.86 | 3.86 |
| 506.99 | 2.94 | 2.94 |
| 508.99 | 3.66 | 3.66 |
| 506.99 | 2.86 | 2.86 |
| 570.00 | 3.02 | 3.02 |
| 452.90 | 2.65 | 2.65 |
| 460.97 | 4.39 | 4.39 |
| 498.59 | 2.83 | 2.83 |
| 492.97 | 2.60 | 2.60 |